Literature DB >> 6101173

Localisation of malignant glioma by a radiolabelled human monoclonal antibody.

J Phillips1, T Alderson, K Sikora, J Watson.   

Abstract

Human monoclonal antibodies were produced by fusing intratumoral lymphocytes from patients with malignant gliomas with a human myeloma line. One antibody was selected for further study after screening for binding activity to glioma cell lines. The patient from whom it was derived developed recurrent glioma. 1 mg of antibody was purified, radiolabelled with 131I, and administered intravenously. The distribution of antibody was determined in the blood, CSF and tumour cyst fluid and compared with that of a control human monoclonal immunoglobulin. Antibody localisation in the tumour was observed and confirmed by external scintiscanning.

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Year:  1983        PMID： 6101173      PMCID： PMC1027384          DOI： 10.1136/jnnp.46.5.388

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  4 in total

1.  Treatment of B-cell lymphoma with monoclonal anti-idiotype antibody.

Authors:  R A Miller; D G Maloney; R Warnke; R Levy
Journal:  N Engl J Med       Date:  1982-03-04       Impact factor: 91.245

2.  Phase-I clinical trial of monoclonal antibody in treatment of gastrointestinal tumours.

Authors:  H F Sears; B Atkinson; J Mattis; C Ernst; D Herlyn; Z Steplewski; P Häyry; H Koprowski
Journal:  Lancet       Date:  1982-04-03       Impact factor: 79.321

3.  Human hybridomas from malignant gliomas.

Authors:  K Sikora; T Alderson; J Phillips; J V Watson
Journal:  Lancet       Date:  1982-01-02       Impact factor: 79.321

4.  A procedure for the fusion of cells in suspension by means of polyethylene glycol.

Authors:  A Hales
Journal:  Somatic Cell Genet       Date:  1977-03
  4 in total
  4 in total

Review 1.  Neuro-oncology index and review (adult primary brain tumors). Radiotherapy, chemotherapy, immunotherapy, photodynamic therapy.

Authors:  M S Mahaley
Journal:  J Neurooncol       Date:  1991-10       Impact factor: 4.130

2.  Intralesional administration of I-131 labelled monoclonal antibodies in the treatment of malignant gliomas.

Authors:  A Arista; C Sturiale; P Riva; V Tison; M Frattarelli; G Moscatelli; G Franceschi; A Spinelli
Journal:  Acta Neurochir (Wien)       Date:  1995       Impact factor: 2.216

3.  Radioimmunolocalization of human brain tumours: biodistribution of radiolabelled monoclonal antibody UJ13A.

Authors:  R B Richardson; A G Davies; S P Bourne; G E Staddon; D H Jones; J T Kemshead; H B Coakham
Journal:  Eur J Nucl Med       Date:  1986

4.  Localization of experimental glioma grafts by means of iodinated monoclonal antibodies and radionuclide imaging.

Authors:  D Stavrou; W Mellert; T Bilzer; R Senekowitsch; E Keiditsch; P Mehraein
Journal:  Acta Neuropathol       Date:  1985       Impact factor: 17.088
  4 in total

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