Literature DB >> 6119412

Human hybridomas from malignant gliomas.

K Sikora, T Alderson, J Phillips, J V Watson.   

Abstract

Intratumoral lymphocytes from 12 patients undergoing craniotomy for malignant glioma were fused with a specially derived human myeloma line LICR-LON-HMy2. 71 stable hybridomas were obtained from 5 of the 12 patients. Such hybridomas had a DNA content equal to the sum of that present in lymphocytes and the parent myeloma. The hybridoma supernatants contained human monoclonal immunoglobulins. Glioma-binding activity was detected in 7 out of the 71 supernatants. These results suggest that malignant gliomas contain a population of B lymphocytes which may be involved in host defence against the tumour.

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Year:  1982        PMID： 6119412     DOI： 10.1016/s0140-6736(82)92556-9

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  19 in total

1.  Human monoclonal antibody. Construction of stable clones reactive with human breast cancer.

Authors:  A J Strelkauskas; C L Taylor
Journal:  Cancer Immunol Immunother       Date:  1986       Impact factor: 6.968

2.  Class differentiation of immunoglobulin-containing cerebrospinal fluid cells in inflammatory diseases of the central nervous system.

Authors:  P Rieckmann; T Weber; K Felgenhauer
Journal:  Klin Wochenschr       Date:  1990-01-04

3.  Construction and testing of mouse--human heteromyelomas for human monoclonal antibody production.

Authors:  N N Teng; K S Lam; F Calvo Riera; H S Kaplan
Journal:  Proc Natl Acad Sci U S A       Date:  1983-12       Impact factor: 11.205

4.  Efficient generation in vitro, from human peripheral blood cells, of monoclonal Epstein-Barr virus transformants producing specific antibody to a variety of antigens without prior deliberate immunization.

Authors:  L Winger; C Winger; P Shastry; A Russell; M Longenecker
Journal:  Proc Natl Acad Sci U S A       Date:  1983-07       Impact factor: 11.205

5.  Monoclonal antibodies to human T lymphocyte surface antigens: their potential application to urology.

Authors:  A W Ritchie; K James; G D Chisholm
Journal:  Urol Res       Date:  1982

6.  Use of monoclonal antibodies and liposomes to improve drug delivery. Present status and future implications.

Authors:  G Gregoriadis
Journal:  Drugs       Date:  1982-10       Impact factor: 9.546

7.  Generation of human monoclonal antibodies reactive with cellular antigens.

Authors:  R J Cote; D M Morrissey; A N Houghton; E J Beattie; H F Oettgen; L J Old
Journal:  Proc Natl Acad Sci U S A       Date:  1983-04       Impact factor: 11.205

8.  Characterization of human hybridomas secreting antibody to tetanus toxoid.

Authors:  J W Larrick; K E Truitt; A A Raubitschek; G Senyk; J C Wang
Journal:  Proc Natl Acad Sci U S A       Date:  1983-10       Impact factor: 11.205

Review 9.  Human monoclonal antibodies.

Authors:  S P Cole; B G Campling; T Atlaw; D Kozbor; J C Roder
Journal:  Mol Cell Biochem       Date:  1984-06       Impact factor: 3.396

10.  Anti-tumor antibody produced by human tumor-infiltrating and peripheral blood B lymphocytes.

Authors:  C J Punt; J A Barbuto; H Zhang; W J Grimes; K D Hatch; E M Hersh
Journal:  Cancer Immunol Immunother       Date:  1994-04       Impact factor: 6.968
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