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Literature DB >> 6099095

Antibody engineering, a strategy for the development of monoclonal antibodies.

Abstract

Antibody engineering is the selection process enabling the isolation of hybridoma clones, each of which produces an antibody with predefined qualities. The state of the art of hybridoma technology is reviewed with emphasis on the results obtained by antibody engineering in our laboratories for the development of monoclonal antibodies for specific use in diagnostic tests. The perspective for in vitro monoclonal antibody production as well as the application of monoclonal antibodies for diagnostic reagents, industrial purification and therapeutic use are indicated.

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Year: 1984 PMID： 6099095 DOI： 10.1007/bf02386229

Source DB: PubMed Journal: Antonie Van Leeuwenhoek ISSN： 0003-6072 Impact factor: 2.271

42 in total

1. A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines.

Authors: J F Kearney; A Radbruch; B Liesegang; K Rajewsky
Journal: J Immunol Date: 1979-10 Impact factor: 5.422

2. The production of monoclonal antibodies from human lymphocytes.

Authors: D Kozbor; J C Roder
Journal: Immunol Today Date: 1983-03

3. Antibodies that react with predetermined sites on proteins.

Authors: J G Sutcliffe; T M Shinnick; N Green; R A Lerner
Journal: Science Date: 1983-02-11 Impact factor: 47.728

4. Tapping the immunological repertoire to produce antibodies of predetermined specificity.

Authors: R A Lerner
Journal: Nature Date: 1982-10-14 Impact factor: 49.962

5. Automated production of monoclonal antibodies in a cytostat.

Authors: S Fazekas de St Groth
Journal: J Immunol Methods Date: 1983-02-25 Impact factor: 2.303

6. Antigen-specific identification and cloning of hybridomas with a fluorescence-activated cell sorter.

Authors: D R Parks; V M Bryan; V T Oi; L A Herzenberg
Journal: Proc Natl Acad Sci U S A Date: 1979-04 Impact factor: 11.205

7. Development, screening and quality specifications of hybridomas synthesizing anti-polypeptide hormone antibodies to be used for diagnostic tests and in-process control.

Authors: O T Schönherr; H W Roelofs; E H Houwink
Journal: Dev Biol Stand Date: 1983

8. Production of human hybridomas secreting antibodies to measles virus.

Authors: C M Croce; A Linnenbach; W Hall; Z Steplewski; H Koprowski
Journal: Nature Date: 1980-12-04 Impact factor: 49.962

9. Human-human hybridomas producing monoclonal antibodies of predefined antigenic specificity.

Authors: L Olsson; H S Kaplan
Journal: Proc Natl Acad Sci U S A Date: 1980-09 Impact factor: 11.205

10. Myocardial infarct imaging of antibodies to canine cardiac myosin with indium-111-diethylenetriamine pentaacetic acid.

Authors: B A Khaw; F T Fallon; H W Strauss; E Haber
Journal: Science Date: 1980-07-11 Impact factor: 47.728

3 in total