Literature DB >> 6094982

Comparative analysis of UV-induced mutability of ten different codon units in position 211 of the Escherichia coli trpA gene.

R Langhammer, R Piechocki.   

Abstract

To study the influence of the local base composition upon UV-induced mutability the reversion frequencies of ten trpA mutants with known codon sequences at position 211 were compared. Comparison of mutant strains reverting by the same base substitution type but with different dipyrimidinic sequences reveals the mutagenic character of the pyrimidine-pyrimidine (6-4) photoproduct. The codons GAC and GAT, both reverting by AT-GC transitions and AT-CG transversions in the middle position and harboring the dipyrimidinic sequence CT in the opposite strand, differ in their reversion frequencies sixfold. This difference can only be due to the influence of the different bases in the third codon position upon the mutability of adjacent second bases.

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Year:  1984        PMID： 6094982     DOI： 10.1007/bf00436204

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  14 in total

1.  Acetylornithinase of Escherichia coli: partial purification and some properties.

Authors:  H J VOGEL; D M BONNER
Journal:  J Biol Chem       Date:  1956-01       Impact factor: 5.157

2.  Studies on a Series of Tryptophan-Independent Strains Derived from a Tryptophan-Requiring Mutant of Escherichia Coli.

Authors:  J Stadler; C Yanofsky
Journal:  Genetics       Date:  1959-01       Impact factor: 4.562

3.  Targeted and untargeted mutagenesis by various inducers of SOS functions in Escherichia coli.

Authors:  E M Witkin; I E Wermundsen
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1979

4.  Nucleotide sequences of trpA of Salmonella typhimurium and Escherichia coli: an evolutionary comparison.

Authors:  B P Nichols; C Yanofsky
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

5.  Some problems in the absolute measurement of germicidal ultraviolet radiation: the use of 'pen ray' lamps as a calibration standard.

Authors:  B Vĕchet
Journal:  Photochem Photobiol       Date:  1974-05       Impact factor: 3.421

6.  Selection for new amino acids at position 211 of the tryptophan synthetase alpha chain of Escherichia coli.

Authors:  E J Murgola; C Yanofsky
Journal:  J Mol Biol       Date:  1974-07-15       Impact factor: 5.469

7.  Genetic studies of the lac repressor. IV. Mutagenic specificity in the lacI gene of Escherichia coli.

Authors:  C Coulondre; J H Miller
Journal:  J Mol Biol       Date:  1977-12-15       Impact factor: 5.469

Review 8.  Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.

Authors:  E M Witkin
Journal:  Bacteriol Rev       Date:  1976-12

9.  Distribution of UV light-induced damage in a defined sequence of human DNA: detection of alkaline-sensitive lesions at pyrimidine nucleoside-cytidine sequences.

Authors:  J A Lippke; L K Gordon; D E Brash; W A Haseltine
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205

10.  Mutational specificity of ultraviolet light in Escherichia coli with and without the R plasmid pKM101.

Authors:  R G Fowler; L McGinty; K E Mortelmans
Journal:  Genetics       Date:  1981-09       Impact factor: 4.562
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  1 in total

1.  Structural determination of the ultraviolet light-induced thymine-cytosine pyrimidine-pyrimidone (6-4) photoproduct.

Authors:  W A Franklin; P W Doetsch; W A Haseltine
Journal:  Nucleic Acids Res       Date:  1985-07-25       Impact factor: 16.971
  1 in total

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