Literature DB >> 6943547

Distribution of UV light-induced damage in a defined sequence of human DNA: detection of alkaline-sensitive lesions at pyrimidine nucleoside-cytidine sequences.

J A Lippke, L K Gordon, D E Brash, W A Haseltine.   

Abstract

The distribution of UV light-induced damage to the highly reiterated alpha sequence of human DNA was investigated. The results show that the distribution of UV light-induced cyclobutane dimers within a defined sequence is similar whether the DNA is exposed to UV light as part of the chromosome of intact cells or as naked DNA. However, the cellular environment shields the nuclear DNA, resulting in about 50% decrease in apparent dose. A new type of UV photodamage was detected. Treatment of UV light-irradiated DNA with hot alkali results in strand breaks at positions of cytidine located 3' to pyrimidine nucleosides. The chemical nature and biological significance of the pyrimidine nucleoside-cytidine lesion is discussed.

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Year:  1981        PMID： 6943547      PMCID： PMC319573          DOI： 10.1073/pnas.78.6.3388

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  21 in total

1.  Homology between human and simian repeated DNA.

Authors:  L Manuelidis; J C Wu
Journal:  Nature       Date:  1978-11-02       Impact factor: 49.962

Review 2.  DNA repair in bacteria and mammalian cells.

Authors:  P C Hanawalt; P K Cooper; A K Ganesan; C A Smith
Journal:  Annu Rev Biochem       Date:  1979       Impact factor: 23.643

3.  Contacts between Escherichia coli RNA polymerase and a lac operon promoter.

Authors:  L Johnsrud
Journal:  Proc Natl Acad Sci U S A       Date:  1978-11       Impact factor: 11.205

4.  DNA sequence at the integration sites of the insertion element IS1.

Authors:  M P Calos; L Johnsrud; J H Miller
Journal:  Cell       Date:  1978-03       Impact factor: 41.582

5.  Molecular basis of base substitution hotspots in Escherichia coli.

Authors:  C Coulondre; J H Miller; P J Farabaugh; W Gilbert
Journal:  Nature       Date:  1978-08-24       Impact factor: 49.962

6.  Subunit structure of chromatin and the organization of eukaryotic highly repetitive DNA: recurrent periodicities and models for the evolutionary origins of repetitive DNA.

Authors:  J J Maio; F L Brown; P R Musich
Journal:  J Mol Biol       Date:  1977-12-15       Impact factor: 5.469

7.  Sequence specific cleavage of DNA by the antitumor antibiotics neocarzinostatin and bleomycin.

Authors:  A D D'Andrea; W A Haseltine
Journal:  Proc Natl Acad Sci U S A       Date:  1978-08       Impact factor: 11.205

8.  The use of DNA fragments of defined sequence for the study of DNA damage and repair.

Authors:  W A Haseltine; C P Lindan; A D D'Andrea; L Johnsrud
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

9.  Purification and properties of the human placental apurinic/apyrimidinic endonuclease.

Authors:  N L Shaper; L Grossman
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

10.  Cleavage of pyrimidine dimers in specific DNA sequences by a pyrimidine dimer DNA-glycosylase of M. luteus.

Authors:  W A Haseltine; L K Gordon; C P Lindan; R H Grafstrom; N L Shaper; L Grossman
Journal:  Nature       Date:  1980-06-26       Impact factor: 49.962
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  58 in total

1.  Photofootprinting of DNA triplexes.

Authors:  V I Lyamichev; O N Voloshin; M D Frank-Kamenetskii; V N Soyfer
Journal:  Nucleic Acids Res       Date:  1991-04-11       Impact factor: 16.971

2.  Unusual conformation of (dA)n.(dT)n-tracts as revealed by cyclobutane thymine-thymine dimer formation.

Authors:  V Lyamichev
Journal:  Nucleic Acids Res       Date:  1991-08-25       Impact factor: 16.971

3.  Neurospora crassa homologue of Neuronal Calcium Sensor-1 has a role in growth, calcium stress tolerance, and ultraviolet survival.

Authors:  Rekha Deka; Ravi Kumar; Ranjan Tamuli
Journal:  Genetica       Date:  2011-07-05       Impact factor: 1.082

4.  Taq DNA polymerase blockage at pyrimidine dimers.

Authors:  R E Wellinger; F Thoma
Journal:  Nucleic Acids Res       Date:  1996-04-15       Impact factor: 16.971

5.  Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers.

Authors:  A Ziegler; D J Leffell; S Kunala; H W Sharma; M Gailani; J A Simon; A J Halperin; H P Baden; P E Shapiro; A E Bale
Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-01       Impact factor: 11.205

6.  Binding of transcription factors creates hot spots for UV photoproducts in vivo.

Authors:  G P Pfeifer; R Drouin; A D Riggs; G P Holmquist
Journal:  Mol Cell Biol       Date:  1992-04       Impact factor: 4.272

7.  Transfection with extracellularly UV-damaged DNA induces human and rat cells to express a mutator phenotype towards parvovirus H-1.

Authors:  C Dinsart; J J Cornelis; B Klein; A J van der Eb; J Rommelaere
Journal:  Mol Cell Biol       Date:  1984-02       Impact factor: 4.272

8.  Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1.

Authors:  Sudhakar Sivasubramaniam; Xuemin Sun; Yen-Ru Pan; Shaohui Wang; Eva Y-H P Lee
Journal:  Genes Dev       Date:  2008-02-18       Impact factor: 11.361

9.  Partial complementation of the UV sensitivity of E. coli and yeast excision repair mutants by the cloned denV gene of bacteriophage T4.

Authors:  J M Chenevert; L Naumovski; R A Schultz; E C Friedberg
Journal:  Mol Gen Genet       Date:  1986-04

10.  Constitutive activation and targeted disruption of signal transducer and activator of transcription 3 (Stat3) in mouse epidermis reveal its critical role in UVB-induced skin carcinogenesis.

Authors:  D J Kim; J M Angel; S Sano; J DiGiovanni
Journal:  Oncogene       Date:  2009-01-12       Impact factor: 9.867
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