Literature DB >> 4022781

Structural determination of the ultraviolet light-induced thymine-cytosine pyrimidine-pyrimidone (6-4) photoproduct.

W A Franklin, P W Doetsch, W A Haseltine.   

Abstract

Ultraviolet light induces damage to DNA, with the majority of the damage expressed as the formation of cyclobutane dimers and pyrimidine-pyrimidone (6-4) photoproducts. The (6-4) photoproducts have been implicated as important UV light-induced premutagenic DNA lesions. The most abundant of the (6-4) products is the thymine-cytosine pyrimidine-pyrimidone (6-4) photoproduct, or TC (6-4) product. The structure of the TC (6-4) product was deduced by proton NMR, IR, and fast atom bombardment mass spectroscopy, and the product was found to differ from the previously described photoadduct, Thy(6-4)Pyo, by the presence of an amino group at the 5 position of the 5' pyrimidine. The implications of this structure on DNA base pairing and the induction of ultraviolet light-induced mutations are discussed.

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Year:  1985        PMID： 4022781      PMCID： PMC321867          DOI： 10.1093/nar/13.14.5317

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  22 in total

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Authors:  S Y Wang; A J Varghese
Journal:  Biochem Biophys Res Commun       Date:  1967-11-30       Impact factor: 3.575

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Journal:  Biochemistry       Date:  1974-10-08       Impact factor: 3.162

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Authors:  A J Varghese; S Y Wang
Journal:  Science       Date:  1967-05-19       Impact factor: 47.728

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Authors:  A J Varghese; M H Patrick
Journal:  Nature       Date:  1969-07-19       Impact factor: 49.962

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Authors:  I L Karle
Journal:  Acta Crystallogr B       Date:  1969-10-15       Impact factor: 2.266

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Journal:  Science       Date:  1969-04-11       Impact factor: 47.728

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Authors:  E M Witkin
Journal:  Bacteriol Rev       Date:  1976-12

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Journal:  Biochemistry       Date:  1970-10-27       Impact factor: 3.162

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Journal:  Biochemistry       Date:  1978-11-14       Impact factor: 3.162
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  18 in total

1.  Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin.

Authors:  F Carrier; P T Georgel; P Pourquier; M Blake; H U Kontny; M J Antinore; M Gariboldi; T G Myers; J N Weinstein; Y Pommier; A J Fornace
Journal:  Mol Cell Biol       Date:  1999-03       Impact factor: 4.272

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Authors:  Shay Covo; Wenjian Ma; James W Westmoreland; Dmitry A Gordenin; Michael A Resnick
Journal:  Cell Cycle       Date:  2012-09-17       Impact factor: 4.534

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Journal:  Proc Natl Acad Sci U S A       Date:  1986-09       Impact factor: 11.205

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Authors:  J D Armstrong; B A Kunz
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

5.  Protein-DNA cross-linking at the lac promoter.

Authors:  M Buckle; J Geiselmann; A Kolb; H Buc
Journal:  Nucleic Acids Res       Date:  1991-02-25       Impact factor: 16.971

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Authors:  G P Pfeifer; R Drouin; A D Riggs; G P Holmquist
Journal:  Mol Cell Biol       Date:  1992-04       Impact factor: 4.272

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Authors:  W L Nicholson; B Setlow; P Setlow
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-01       Impact factor: 11.205

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Authors:  D E Szymkowski; C W Lawrence; R D Wood
Journal:  Proc Natl Acad Sci U S A       Date:  1993-11-01       Impact factor: 11.205

9.  UV light-induced cyclobutane pyrimidine dimers are mutagenic in mammalian cells.

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Journal:  Mol Cell Biol       Date:  1986-10       Impact factor: 4.272

10.  An ultraviolet light-damaged DNA recognition protein absent in xeroderma pigmentosum group E cells binds selectively to pyrimidine (6-4) pyrimidone photoproducts.

Authors:  D K Treiber; Z Chen; J M Essigmann
Journal:  Nucleic Acids Res       Date:  1992-11-11       Impact factor: 16.971
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