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Literature DB >> 6093542

Growth-hormone-releasing factor immunoreactivity in human endocrine tumors.

D G Bostwick, R Quan, A R Hoffman, R J Webber, J K Chang, K G Bensch.

Abstract

Seventy-three human tumors and adjacent nonneoplastic tissues were analyzed immunohistochemically for the presence of growth-hormone-releasing factor (GRF). Four of 9 pancreatic endocrine tumors, 2 of 3 appendiceal carcinoids, and 1 of 5 cecal carcinoids were immunoreactive for GRF. One of the GRF-containing pancreatic tumors was associated with acromegaly. Histologically, the growth patterns of these tumors were variable, and the distribution of immunoreactive cells was patchy and irregular. There were no normal cells that contained GRF. These results indicate that GRF production by human tumors is more common than previously thought, although clinical acromegaly may not be apparent in patients who harbor such neoplasms.

Entities: Disease Gene Species

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Year: 1984 PMID： 6093542 PMCID： PMC1900448

Source DB: PubMed Journal: Am J Pathol ISSN： 0002-9440 Impact factor: 4.307

10 in total

1. Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour.

Authors: J Rivier; J Spiess; M Thorner; W Vale
Journal: Nature Date: 1982-11-18 Impact factor: 49.962

2. Production of immunoreactive pancreatic growth hormone-releasing factor in small cell carcinoma of the lung.

Authors: K Yamaguchi; K Abe; M Suzuki; I Adachi; S Kimura; A Shimada; H Ohno; A Kanai; T Kameya
Journal: Gan Date: 1983-12

3. Distribution of growth hormone-releasing hormone-like immunoreactivity in human tissue extracts.

Authors: T Shibasaki; Y Kiyosawa; A Masuda; M Nakahara; T Imaki; I Wakabayashi; H Demura; K Shizume; N Ling
Journal: J Clin Endocrinol Metab Date: 1984-08 Impact factor: 5.958

Review 4. Ectopic secretion of a growth hormone-releasing factor. Report of a case of acromegaly with bronchial carcinoid tumor.

Authors: B W Scheithauer; P C Carpenter; B Bloch; P Brazeau
Journal: Am J Med Date: 1984-04 Impact factor: 4.965

5. Human hypothalamic growth hormone releasing factor (GRF): evidence for two forms identical to tumor derived GRF-44-NH2 and GRF-40.

Authors: P Böhlen; P Brazeau; B Bloch; N Ling; R Gaillard; R Guillemin
Journal: Biochem Biophys Res Commun Date: 1983-08-12 Impact factor: 3.575

6. Cloning and sequence analysis of cDNA for the precursor of human growth hormone-releasing factor, somatocrinin.

Authors: U Gubler; J J Monahan; P T Lomedico; R S Bhatt; K J Collier; B J Hoffman; P Böhlen; F Esch; N Ling; F Zeytin; P Brazeau; M S Poonian; L P Gage
Journal: Proc Natl Acad Sci U S A Date: 1983-07 Impact factor: 11.205

7. Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly.

Authors: R Guillemin; P Brazeau; P Böhlen; F Esch; N Ling; W B Wehrenberg
Journal: Science Date: 1982-11-05 Impact factor: 47.728

8. The neuroendocrine products of intestinal carcinoids. An immunoperoxidase study of 35 carcinoid tumors stained for serotonin and eight polypeptide hormones.

Authors: K Yang; T Ulich; L Cheng; K J Lewin
Journal: Cancer Date: 1983-05-15 Impact factor: 6.860

9. Acromegaly and Cushing's syndrome associated with a foregut carcinoid tumor.

Authors: S A Leveston; D W McKeel; P J Buckley; K Deschryver; M H Greider; B M Jaffe; W H Daughaday
Journal: J Clin Endocrinol Metab Date: 1981-10 Impact factor: 5.958

10. Immunohistochemical detection of growth hormone-releasing factor in brain.

Authors: B Bloch; P Brazeau; N Ling; P Bohlen; F Esch; W B Wehrenberg; R Benoit; F Bloom; R Guillemin
Journal: Nature Date: 1983 Feb 17-23 Impact factor: 49.962