Literature DB >> 6812220

Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly.

R Guillemin, P Brazeau, P Böhlen, F Esch, N Ling, W B Wehrenberg.   

Abstract

A 44 amino acid peptide with growth hormone-releasing activity has been isolated from a human tumor of the pancreas that had caused acromegaly. The primary structure of the tumor-derived peptide is H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala- Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly -Ala-Arg-Ala-Arg-Leu-NH2. The synthetic replicate has full biological activity in vitro and in vivo specifically to stimulate the secretion of immunoreactive growth hormone. The tumor-derived peptide is identical in biological activity and similar in physiochemical properties to the still uncharacterized growth hormone-releasing factor present in extracts of hypothalamic tissues.

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Year:  1982        PMID： 6812220     DOI： 10.1126/science.6812220

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  159 in total

Review 1.  A history of acromegaly.

Authors:  R Sheaves
Journal:  Pituitary       Date:  1999-06       Impact factor: 4.107

2.  Peptides derived from pro-growth hormone-releasing hormone activate p38 mitogen-activated protein kinase in GH3 pituitary cells.

Authors:  R Steinmetz; P Zeng; D W King; E Walvoord; O H Pescovitz
Journal:  Endocrine       Date:  2001-06       Impact factor: 3.633

3.  Effects of growth hormone-releasing hormone (GHRH) on densely granulated somatotroph adenomas and sparsely granulated somatotroph adenomas in vitro: a morphological and functional investigation.

Authors:  S Kawakita; S L Asa; K Kovacs
Journal:  J Endocrinol Invest       Date:  1989 Jul-Aug       Impact factor: 4.256

4.  Growth hormone-releasing factor regulates growth hormone mRNA in primary cultures of rat pituitary cells.

Authors:  G G Gick; F N Zeytin; P Brazeau; N C Ling; F S Esch; C Bancroft
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205

5.  Metabolic clearance and plasma disappearance rates of human pancreatic tumor growth hormone releasing factor in man.

Authors:  L A Frohman; J L Thominet; C B Webb; M L Vance; H Uderman; J Rivier; W Vale; M O Thorner
Journal:  J Clin Invest       Date:  1984-05       Impact factor: 14.808

6.  Human pancreatic growth hormone-releasing factor (hpGRF): dose-response of GRF- and GH-levels.

Authors:  M Losa; G K Stalla; O A Müller; K von Werder
Journal:  Klin Wochenschr       Date:  1983-12-15

7.  Plasma growth hormone responses to constant infusions of human pancreatic growth hormone releasing factor. Intermittent secretion or response attenuation.

Authors:  C B Webb; M L Vance; M O Thorner; G Perisutti; J Thominet; J Rivier; W Vale; L A Frohman
Journal:  J Clin Invest       Date:  1984-07       Impact factor: 14.808

8.  Growth-hormone releasing factor does not antagonize somatostatin effects on pancreatic and gastric secretions.

Authors:  M Chovet; M Dubrasquet; J Chariot; C Rozé
Journal:  Experientia       Date:  1985-11-15

9.  Human pancreatic growth hormone-releasing factor (hpGRF-44) in acromegaly before and after adenomectomy. Modifications induced by somatostatin (GHRIH) infusion.

Authors:  M Arosio; B Ambrosi; L Guglielmino; G Faglia
Journal:  J Endocrinol Invest       Date:  1985-10       Impact factor: 4.256

10.  Isolation, primary structure, and synthesis of human hypothalamic somatocrinin: growth hormone-releasing factor.

Authors:  N Ling; F Esch; P Böhlen; P Brazeau; W B Wehrenberg; R Guillemin
Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205
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