Literature DB >> 6092873

Mutagenic repair in Escherichia coli. X. The umuC gene product may be required for replication past pyrimidine dimers but not for the coding error in UV-mutagenesis.

B A Bridges, R Woodgate.   

Abstract

Bacteria of strain TK610 uvrA-6 his-4 umuC-36, when allowed to replicate their DNA for some hours after irradiation show induction of His+ mutations when subsequently exposed to visible light. It is suggested that base pair errors can be made opposite sites of pyrimidine dimers without involvement of umuC gene product but that the latter is required for continued replication past the dimer-mismatch region. Removal of the pyrimidine dimer by photoreversal allows replication to continue thus fixing the mismatched base as as mutation.

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Year:  1984        PMID： 6092873     DOI： 10.1007/bf00328073

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  17 in total

1.  Mutants of Escherichia coli requiring methionine or vitamin B12.

Authors:  B D DAVIS; E S MINGIOLI
Journal:  J Bacteriol       Date:  1950-07       Impact factor: 3.490

2.  Isolation and characterization of mutants of Escherichia coli deficient in induction of mutations by ultraviolet light.

Authors:  T Kato; Y Shinoura
Journal:  Mol Gen Genet       Date:  1977-11-14

3.  Molecular mechanisms of induced mutagenesis. Replication in vivo of bacteriophage phiX174 single-stranded, ultraviolet light-irradiated DNA in intact and irradiated host cells.

Authors:  P Caillet-Fauquet; M Defais; M Radman
Journal:  J Mol Biol       Date:  1977-11-25       Impact factor: 5.469

4.  Survival, mutation and capacity to repair single-strand DNA breaks after gamma irradiation in different Exr - strains of Escherichia coli.

Authors:  S G Sedgwick; B A Bridges
Journal:  Mol Gen Genet       Date:  1972

5.  Mutagenesis in Escherichia coli: evidence for the mechanism of base change mutation by ultraviolet radiation in a strain deficient in excision-repair.

Authors:  B A Bridges; R J Munson
Journal:  Proc R Soc Lond B Biol Sci       Date:  1968-11-05

Review 6.  Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.

Authors:  E M Witkin
Journal:  Bacteriol Rev       Date:  1976-12

7.  Misrepair of overlapping daughter strand gaps as a possible mechanism for UV induced mutagenesis in UVR strains of Escherichia coli: a general model for induced mutagenesis by misrepair (SOS repair) of closely spaced DNA lesions.

Authors:  S G Sedgwick
Journal:  Mutat Res       Date:  1976-12       Impact factor: 2.433

8.  Contribution of 3' leads to 5' exonuclease activity of DNA polymerase III holoenzyme from Escherichia coli to specificity.

Authors:  A R Fersht; J W Knill-Jones
Journal:  J Mol Biol       Date:  1983-04-25       Impact factor: 5.469

9.  Role of the E. coli umuC gene product in the repair of single-stranded DNA phage.

Authors:  M Defais
Journal:  Mol Gen Genet       Date:  1983

10.  Cleavage of the Escherichia coli lexA protein by the recA protease.

Authors:  J W Little; S H Edmiston; L Z Pacelli; D W Mount
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205
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  38 in total

1.  Intrinsic polymerase activities of UmuD'(2)C and MucA'(2)B are responsible for their different mutagenic properties during bypass of a T-T cis-syn cyclobutane dimer.

Authors:  P I O'Grady; A Borden; D Vandewiele; A Ozgenc; R Woodgate; C W Lawrence
Journal:  J Bacteriol       Date:  2000-04       Impact factor: 3.490

Review 2.  Mutagenesis after exposure of bacteria to ultraviolet light and delayed photoreversal.

Authors:  B A Bridges
Journal:  Mol Gen Genet       Date:  1992-06

3.  Substitution of mucAB or rumAB for umuDC alters the relative frequencies of the two classes of mutations induced by a site-specific T-T cyclobutane dimer and the efficiency of translesion DNA synthesis.

Authors:  E S Szekeres; R Woodgate; C W Lawrence
Journal:  J Bacteriol       Date:  1996-05       Impact factor: 3.490

4.  UmuC mutagenesis protein of Escherichia coli: purification and interaction with UmuD and UmuD'.

Authors:  R Woodgate; M Rajagopalan; C Lu; H Echols
Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205

5.  groE mutants of Escherichia coli are defective in umuDC-dependent UV mutagenesis.

Authors:  C E Donnelly; G C Walker
Journal:  J Bacteriol       Date:  1989-11       Impact factor: 3.490

6.  Specificity of mutation by UV light and delayed photoreversal in umuC-defective Escherichia coli K-12: a targeting intermediate at pyrimidine dimers.

Authors:  R Bockrath; M Ruiz-Rubio; B A Bridges
Journal:  J Bacteriol       Date:  1987-04       Impact factor: 3.490

7.  An in vivo complex with DNA photolyase blocks UV mutagenesis targeted at a thymine-cytosine dimer in Escherichia coli.

Authors:  M Ruiz-Rubio; K Yamamoto; R Bockrath
Journal:  J Bacteriol       Date:  1988-11       Impact factor: 3.490

8.  Functional recA, lexA, umuD, umuC, polA, and polB genes are not required for the Escherichia coli UVM response.

Authors:  V A Palejwala; G E Wang; H S Murphy; M Z Humayun
Journal:  J Bacteriol       Date:  1995-11       Impact factor: 3.490

9.  The active form of DNA polymerase V is UmuD'(2)C-RecA-ATP.

Authors:  Qingfei Jiang; Kiyonobu Karata; Roger Woodgate; Michael M Cox; Myron F Goodman
Journal:  Nature       Date:  2009-07-16       Impact factor: 49.962

10.  Biochemical basis of SOS-induced mutagenesis in Escherichia coli: reconstitution of in vitro lesion bypass dependent on the UmuD'2C mutagenic complex and RecA protein.

Authors:  M Tang; I Bruck; R Eritja; J Turner; E G Frank; R Woodgate; M O'Donnell; M F Goodman
Journal:  Proc Natl Acad Sci U S A       Date:  1998-08-18       Impact factor: 11.205
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