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Literature DB >> 6087315

Avian myeloblastosis virus and E26 virus oncogene products are nuclear proteins.

W J Boyle, M A Lampert, J S Lipsick, M A Baluda.

Abstract

The defective acute leukemia viruses avian myeloblastosis virus (AMV) and E26 virus each contain an inserted cellular sequence related to the same highly conserved cellular gene, proto-amv. The oncogenes of these two retroviruses differ from this cellular proto-oncogene in gene structure, transcript structure, and gene product. The product of the AMV oncogene (myb) is a 48,000 Mr protein, p48myb, encoded by a transduced segment (amv) of proto-amv flanked by short helper-virus-derived terminal sequences. The E26 virus oncogene product is a 135,000 Mr protein, p135gag-amve-ets, encoded by significant portions of a viral structural gene (gag), sequences related to proto-amv (amve), and additional E26-specific sequences (ets) transduced from cellular proto-ets. Both p48myb and p135gag-amve-ets transforming proteins are located in the nucleus of cells transformed by these viruses. A protein of 110,000 Mr which is specifically immunoprecipitated by antisera to amv peptides and may be the product of the normal cellular gene (proto-amv) has been located in the cytoplasm of cells that express proto-amv mRNA.

Entities: Disease Species

Mesh：

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Year: 1984 PMID： 6087315 PMCID： PMC345568 DOI： 10.1073/pnas.81.14.4265

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

38 in total

1. Transcripts from the cellular homologs of retroviral oncogenes: distribution among chicken tissues.

Authors: T J Gonda; D K Sheiness; J M Bishop
Journal: Mol Cell Biol Date: 1982-06 Impact factor: 4.272

2. Three new types of viral oncogene of cellular origin specific for haematopoietic cell transformation.

Authors: M Roussel; S Saule; C Lagrou; C Rommens; H Beug; T Graf; D Stehelin
Journal: Nature Date: 1979-10-11 Impact factor: 49.962

3. Evidence that the src gene product of Rous sarcoma virus is membrane associated.

Authors: J G Krueger; E Wang; A R Goldberg
Journal: Virology Date: 1980-02 Impact factor: 3.616

4. Two cell lines from lymphomas of Marek's disease.

Authors: Y Akiyama; S Kato
Journal: Biken J Date: 1974-09

5. Preparation of syngeneic tumor regressor serum reactive with the unique determinants of the Abelson murine leukemia virus-encoded P120 protein at the cell surface.

Authors: O N Witte; N Rosenberg; D Baltimore
Journal: J Virol Date: 1979-09 Impact factor: 5.103

6. Localization of the ASV src gene product to the plasma membrane of transformed cells by electron microscopic immunocytochemistry.

Authors: M C Willingham; G Jay; I Pastan
Journal: Cell Date: 1979-09 Impact factor: 41.582

7. The transforming protein of Moloney murine sarcoma virus is a soluble cytoplasmic protein.

Authors: J Papkoff; E A Nigg; T Hunter
Journal: Cell Date: 1983-05 Impact factor: 41.582

8. Adhesion plaques of Rous sarcoma virus-transformed cells contain the src gene product.

Authors: L R Rohrschneider
Journal: Proc Natl Acad Sci U S A Date: 1980-06 Impact factor: 11.205

9. Association of the src gene product of Rous sarcoma virus with cytoskeletal structures of chicken embryo fibroblasts.

Authors: J G Burr; G Dreyfuss; S Penman; J M Buchanan
Journal: Proc Natl Acad Sci U S A Date: 1980-06 Impact factor: 11.205

10. Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry.

Authors: M C Willingham; I Pastan; T Y Shih; E M Scolnick
Journal: Cell Date: 1980-04 Impact factor: 41.582

39 in total

1. Subnuclear localization of the trans-activating protein of human T-cell leukemia virus type I.

Authors: D J Slamon; W J Boyle; D E Keith; M F Press; D W Golde; L M Souza
Journal: J Virol Date: 1988-03 Impact factor: 5.103

2. Definition of functional domains in P135gag-myb-ets and p48v-myb proteins required to maintain the response of neuroretina cells to basic fibroblast growth factor.

Authors: C Garrido; D Leprince; J S Lipsick; D Stehelin; D Gospodarowicz; S Saule
Journal: J Virol Date: 1992-01 Impact factor: 5.103

Avian myeloblastosis virus and E26 virus oncogene products are nuclear proteins.

1. Transcripts from the cellular homologs of retroviral oncogenes: distribution among chicken tissues.

2. Three new types of viral oncogene of cellular origin specific for haematopoietic cell transformation.

3. Evidence that the src gene product of Rous sarcoma virus is membrane associated.

4. Two cell lines from lymphomas of Marek's disease.

5. Preparation of syngeneic tumor regressor serum reactive with the unique determinants of the Abelson murine leukemia virus-encoded P120 protein at the cell surface.

6. Localization of the ASV src gene product to the plasma membrane of transformed cells by electron microscopic immunocytochemistry.

7. The transforming protein of Moloney murine sarcoma virus is a soluble cytoplasmic protein.

8. Adhesion plaques of Rous sarcoma virus-transformed cells contain the src gene product.

9. Association of the src gene product of Rous sarcoma virus with cytoskeletal structures of chicken embryo fibroblasts.

10. Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry.

1. Subnuclear localization of the trans-activating protein of human T-cell leukemia virus type I.

2. Definition of functional domains in P135gag-myb-ets and p48v-myb proteins required to maintain the response of neuroretina cells to basic fibroblast growth factor.

3. Transformation by v-myb correlates with trans-activation of gene expression.

4. v-myb does not prevent the expression of c-myb in avian erythroblasts.

5. DNA-binding activity associated with the v-myb oncogene product is not sufficient for transformation.

6. Isolation of human cDNA clones of myb-related genes, A-myb and B-myb.

7. Coordinate regulation of myelomonocytic phenotype by v-myb and v-myc.

8. Multiple domains for the chicken cellular sequences homologous to the v-ets oncogene of the E26 retrovirus.

9. trans activation of gene expression by v-myb.

10. v-myb blocks granulocyte colony-stimulating factor-induced myeloid cell differentiation but not proliferation.