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Literature DB >> 2845150

DNA-binding activity associated with the v-myb oncogene product is not sufficient for transformation.

C E Ibanez¹, A Garcia, U Stober-Grässer, J S Lipsick.

Abstract

The product of the v-myb oncogene of avian myeloblastosis virus is a nuclear protein with an associated DNA-binding activity. We demonstrated that the highly conserved amino-terminal domain of p48v-myb is required for its associated DNA-binding activity. This activity is not required for the nuclear localization of p48v-myb. Furthermore, the associated DNA-binding activity and nuclear localization of p48v-myb together are not sufficient for transformation.

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Year: 1988 PMID： 2845150 PMCID： PMC253882

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

39 in total

Review 1. The myb oncogene.

Authors: J S Lipsick; M A Baluda
Journal: Gene Amplif Anal Date: 1986

2. The protein products of the myc and myb oncogenes and adenovirus E1a are structurally related.

Authors: R Ralston; J M Bishop
Journal: Nature Date: 1983 Dec 22-1984 Jan 4 Impact factor: 49.962

3. Subcellular localization of proteins encoded by oncogenes of avian myeloblastosis virus and avian leukemia virus E26 and by chicken c-myb gene.

Authors: K H Klempnauer; G Symonds; G I Evan; J M Bishop
Journal: Cell Date: 1984-06 Impact factor: 41.582

4. Proposed alpha-helical super-secondary structure associated with protein-dna recognition.

Authors: W F Anderson
Journal: J Mol Biol Date: 1982-08-25 Impact factor: 5.469

5. Homology among DNA-binding proteins suggests use of a conserved super-secondary structure.

Authors: R T Sauer; R R Yocum; R F Doolittle; M Lewis; C O Pabo
Journal: Nature Date: 1982-07-29 Impact factor: 49.962

6. Differential expression of the amv gene in human hematopoietic cells.

Authors: E H Westin; R C Gallo; S K Arya; A Eva; L M Souza; M A Baluda; S A Aaronson; F Wong-Staal
Journal: Proc Natl Acad Sci U S A Date: 1982-04 Impact factor: 11.205

7. Avian myeloblastosis virus and E26 virus oncogene products are nuclear proteins.

Authors: W J Boyle; M A Lampert; J S Lipsick; M A Baluda
Journal: Proc Natl Acad Sci U S A Date: 1984-07 Impact factor: 11.205

8. Cellular sequences are present in the presumptive avian myeloblastosis virus genome.

Authors: L M Souza; J N Strommer; R L Hillyard; M C Komaromy; M A Baluda
Journal: Proc Natl Acad Sci U S A Date: 1980-09 Impact factor: 11.205

9. Identification of the leukemogenic protein of avian myeloblastosis virus and of its normal cellular homologue.

Authors: W J Boyle; J S Lipsick; E P Reddy; M A Baluda
Journal: Proc Natl Acad Sci U S A Date: 1983-05 Impact factor: 11.205

10. The product of the retroviral transforming gene v-myb is a truncated version of the protein encoded by the cellular oncogene c-myb.

Authors: K H Klempnauer; G Ramsay; J M Bishop; M G Moscovici; C Moscovici; J P McGrath; A D Levinson
Journal: Cell Date: 1983-06 Impact factor: 41.582

7 in total

7. A conserved acidic patch in the Myb domain is required for activation of an endogenous target gene and for chromatin binding.

Authors: Emily Ray Ko; Dennis Ko; Carolyn Chen; Joseph S Lipsick
Journal: Mol Cancer Date: 2008-10-07 Impact factor: 27.401

7 in total

DNA-binding activity associated with the v-myb oncogene product is not sufficient for transformation.

Review 1. The myb oncogene.

2. The protein products of the myc and myb oncogenes and adenovirus E1a are structurally related.

3. Subcellular localization of proteins encoded by oncogenes of avian myeloblastosis virus and avian leukemia virus E26 and by chicken c-myb gene.

4. Proposed alpha-helical super-secondary structure associated with protein-dna recognition.

5. Homology among DNA-binding proteins suggests use of a conserved super-secondary structure.

6. Differential expression of the amv gene in human hematopoietic cells.

7. Avian myeloblastosis virus and E26 virus oncogene products are nuclear proteins.

8. Cellular sequences are present in the presumptive avian myeloblastosis virus genome.

9. Identification of the leukemogenic protein of avian myeloblastosis virus and of its normal cellular homologue.

10. The product of the retroviral transforming gene v-myb is a truncated version of the protein encoded by the cellular oncogene c-myb.

1. Transformation by v-myb correlates with trans-activation of gene expression.

2. trans activation of gene expression by v-myb.

3. Functional analysis of carboxy-terminal deletion mutants of c-Myb.

4. Individual repeats of Drosophila Myb can function in transformation by v-Myb.

5. Oncogenic truncation of the first repeat of c-Myb decreases DNA binding in vitro and in vivo.

6. Characterization of the sequence-specific interaction of mouse c-myb protein with DNA.

7. A conserved acidic patch in the Myb domain is required for activation of an endogenous target gene and for chromatin binding.