Literature DB >> 6084812

Transcription of the mouse dihydrofolate reductase gene proceeds unabated through seven polyadenylation sites and terminates near a region of repeated DNA.

E G Frayne, E J Leys, G F Crouse, A G Hook, R E Kellems.   

Abstract

We observed equimolar transcription throughout the 35-kilobase mouse dihydrofolate reductase structural gene. Transcription termination occurred within a discrete region (900 base pairs) located 1 kilobase beyond the last of seven functional polyadenylation sites and near a repetitive DNA sequence element. The results imply that a distinct genetic signal may be associated with the process of transcription termination.

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Year:  1984        PMID： 6084812      PMCID： PMC369306          DOI： 10.1128/mcb.4.12.2921-2924.1984

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  24 in total

1.  Relation of folic acid reductase to amethopterin resistance in cultured mammalian cells.

Authors:  M T HAKALA; S F ZAKRZEWSKI; C A NICHOL
Journal:  J Biol Chem       Date:  1961-03       Impact factor: 5.157

2.  Transcription pattern of in vivo-labeled late simian virus 40 RNA: equimolar transcription beyond the mRNA 3' terminus.

Authors:  J P Ford; M T Hsu
Journal:  J Virol       Date:  1978-12       Impact factor: 5.103

3.  Synthesis and degradation of folate reductase in sensitive and methotrexate-resistant lines of S-180 cells.

Authors:  F W Alt; R E Kellems; R T Schimke
Journal:  J Biol Chem       Date:  1976-05-25       Impact factor: 5.157

4.  Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase.

Authors:  A C Chang; J H Nunberg; R J Kaufman; H A Erlich; R T Schimke; S N Cohen
Journal:  Nature       Date:  1978-10-19       Impact factor: 49.962

5.  Transcriptional regulation of hemoglobin switching in chicken embryos.

Authors:  M Groudine; M Peretz; H Weintraub
Journal:  Mol Cell Biol       Date:  1981-03       Impact factor: 4.272

6.  A family of moderately repetitive sequences in mouse DNA.

Authors:  S M Cheng; C L Schildkraut
Journal:  Nucleic Acids Res       Date:  1980-09-25       Impact factor: 16.971

7.  Structure and genomic organization of the mouse dihydrofolate reductase gene.

Authors:  J H Nunberg; R J Kaufman; A C Chang; S N Cohen; R T Schimke
Journal:  Cell       Date:  1980-02       Impact factor: 41.582

8.  Steps in the processing of Ad2 mRNA: poly(A)+ nuclear sequences are conserved and poly(A) addition precedes splicing.

Authors:  J R Nevins; J E Darnell
Journal:  Cell       Date:  1978-12       Impact factor: 41.582

9.  Transcriptional regulation of the ovalbumin and conalbumin genes by steroid hormones in chick oviduct.

Authors:  G S McKnight; R D Palmiter
Journal:  J Biol Chem       Date:  1979-09-25       Impact factor: 5.157

10.  Size heterogeneity in the 3' end of dihydrofolate reductase messenger RNAs in mouse cells.

Authors:  D R Setzer; M McGrogan; J H Nunberg; R T Schimke
Journal:  Cell       Date:  1980-11       Impact factor: 41.582
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  27 in total

1.  Cell-type-specific synthesis of murine immunoglobulin mu RNA from an adenovirus vector.

Authors:  J E Ruether; A Maderious; D Lavery; J Logan; S M Fu; S Chen-Kiang
Journal:  Mol Cell Biol       Date:  1986-01       Impact factor: 4.272

Review 2.  Alternative poly(A) site selection in complex transcription units: means to an end?

Authors:  G Edwalds-Gilbert; K L Veraldi; C Milcarek
Journal:  Nucleic Acids Res       Date:  1997-07-01       Impact factor: 16.971

3.  RNA polymerase II terminates transcription in vitro in the SV40 origin region.

Authors:  D S Grass; R Jove; J L Manley
Journal:  Nucleic Acids Res       Date:  1987-06-11       Impact factor: 16.971

4.  Requirements for accurate and efficient mRNA 3' end cleavage and polyadenylation of a simian virus 40 early pre-RNA in vitro.

Authors:  L C Ryner; J L Manley
Journal:  Mol Cell Biol       Date:  1987-01       Impact factor: 4.272

5.  Identification of sequences in the herpes simplex virus thymidine kinase gene required for efficient processing and polyadenylation.

Authors:  C N Cole; T P Stacy
Journal:  Mol Cell Biol       Date:  1985-08       Impact factor: 4.272

6.  DNA sequences downstream of the adenovirus type 2 fiber polyadenylation site contain transcription termination signals.

Authors:  G R Dressler; N W Fraser
Journal:  J Virol       Date:  1987-09       Impact factor: 5.103

7.  A poly(A) addition site and a downstream termination region are required for efficient cessation of transcription by RNA polymerase II in the mouse beta maj-globin gene.

Authors:  J Logan; E Falck-Pedersen; J E Darnell; T Shenk
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

8.  Transcription termination at the chicken beta H-globin gene.

Authors:  T M Pribyl; H G Martinson
Journal:  Mol Cell Biol       Date:  1988-12       Impact factor: 4.272

9.  Transcription boundaries of U1 small nuclear RNA.

Authors:  G R Kunkel; T Pederson
Journal:  Mol Cell Biol       Date:  1985-09       Impact factor: 4.272

10.  Characterization of cDNA sequences corresponding to three distinct HMG-1 mRNA species in line CHO Chinese hamster cells and cell cycle expression of the HMG-1 gene.

Authors:  K L Lee; B T Pentecost; J A D'Anna; R A Tobey; L R Gurley; G H Dixon
Journal:  Nucleic Acids Res       Date:  1987-07-10       Impact factor: 16.971
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