Literature DB >> 596321

Comparative studies of the protein binding of digoxin and its metabolites.

P H Hinderling.   

Abstract

The protein binding of Digoxin (D), Dihydrodigoxin (DH), Digoxigenin Bisdigitoxoside (DB) and Digoxigenin Monodigitoxoside (DM) was concentration independent and unaltered by the presence of high concentrations of the analogous compounds. The respective percentage of protein binding for D, DH, DB and DM were 22%, 22%, 23% and 27%.

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Year:  1977        PMID： 596321     DOI： 10.1007/bf01969571

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  9 in total

1.  The measurement of urinary digoxin and dihydrodigoxin by radioimmunoassay and by mass spectroscopy.

Authors:  H Greenwood; W Snedden; R P Hayward; J Landon
Journal:  Clin Chim Acta       Date:  1975-07-23       Impact factor: 3.786

2.  Pharmacokinetics and metabolism of digoxin- and beta-methyl-digoxin-12aplha-3 H in patients with acute hepatitis.

Authors:  W Zilly; E Richter; N Rietbrock
Journal:  Clin Pharmacol Ther       Date:  1975-03       Impact factor: 6.875

3.  Uraemic and normal plasma protein binding of various cardiac glycosides under "in vivo" conditions.

Authors:  P Kramer; E Köthe; F Scheler
Journal:  Eur J Clin Invest       Date:  1974-02       Impact factor: 4.686

4.  Absorption of digoxin from different oral preparations in normal subjects during steady state.

Authors:  D H Huffman; C V Manion; D L Azarnoff
Journal:  Clin Pharmacol Ther       Date:  1974-08       Impact factor: 6.875

5.  The binding of digoxin by the serum proteins.

Authors:  D C Evered
Journal:  Eur J Pharmacol       Date:  1972-05       Impact factor: 4.432

6.  Dihydrodigoxin: a common metabolite of digoxin in man.

Authors:  D R Clark; S M Kalman
Journal:  Drug Metab Dispos       Date:  1974 Mar-Apr       Impact factor: 3.922

7.  Tritium-labelled cardiac glycosides: digoxin-[12-alpha-3H].

Authors:  A Wartburg; F Kalberer; J Rutschmann
Journal:  Biochem Pharmacol       Date:  1965-12       Impact factor: 5.858

8.  Studies on digitalis. V. The influence of impaired renal function, hemodialysis, and drug interaction on serum protein binding of digitoxin and digoxin.

Authors:  L Storstein
Journal:  Clin Pharmacol Ther       Date:  1976-07       Impact factor: 6.875

Review 9.  Clinical pharmacokinetics of digoxin.

Authors:  E Iisalo
Journal:  Clin Pharmacokinet       Date:  1977 Jan-Feb       Impact factor: 6.447
  9 in total
  4 in total

1.  Population pharmacokinetics of doripenem based on data from phase 1 studies with healthy volunteers and phase 2 and 3 studies with critically ill patients.

Authors:  Partha Nandy; Mahesh N Samtani; Rachel Lin
Journal:  Antimicrob Agents Chemother       Date:  2010-04-12       Impact factor: 5.191

Review 2.  Clinical pharmacokinetics of digoxin 1980.

Authors:  J K Aronson
Journal:  Clin Pharmacokinet       Date:  1980 Mar-Apr       Impact factor: 6.447

3.  A standard approach to compiling clinical pharmacokinetic data.

Authors:  L B Sheiner; L Z Benet; L A Pagliaro
Journal:  J Pharmacokinet Biopharm       Date:  1981-02

4.  Atropine: a sensitive gas chromatography-mass spectrometry assay and prepharmacokinetic studies.

Authors:  M Eckert; P H Hinderling
Journal:  Agents Actions       Date:  1981-11
  4 in total

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