Literature DB >> 1120395

Pharmacokinetics and metabolism of digoxin- and beta-methyl-digoxin-12aplha-3 H in patients with acute hepatitis.

W Zilly, E Richter, N Rietbrock.   

Abstract

Pharmocokinetics and metabolism of digoxin and beta-methyldigoxin have been studied in patients with acute hepatits after intravenous administration of both H-labeled glycosides. In contrast to digoxin, the rate of decline of radioactivity after administration of beta-methyldigoxin was significantly retarded in patients with acute hepatitis. The increase in plasma concentration after beta-methyldigoxin to patients with acute hepatitis is probably related to decreased demethylation.

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Year:  1975        PMID： 1120395     DOI： 10.1002/cpt1975173302

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  13 in total

Review 1.  Critical compilation of terminal half-lives, percent excreted unchanged, and changes of half-life in renal and hepatic dysfunction for studies in humans with references.

Authors:  L A Pagliaro; L Z Benet
Journal:  J Pharmacokinet Biopharm       Date:  1975-10

Review 2.  Therapeutic drug monitoring of antiarrhythmic drugs.

Authors:  Gesche Jürgens; Niels A Graudal; Jens P Kampmann
Journal:  Clin Pharmacokinet       Date:  2003       Impact factor: 6.447

3.  Bioavailability and pharmacokinetics of beta-methyldigoxin after multiple oral and intravenous doses.

Authors:  N Rietbrock; J Guggenmos; J Kuhlmann; U Hess
Journal:  Eur J Clin Pharmacol       Date:  1976-03-22       Impact factor: 2.953

Review 4.  Guide to drug dosage in hepatic disease.

Authors:  N M Bass; R L Williams
Journal:  Clin Pharmacokinet       Date:  1988-12       Impact factor: 6.447

Review 5.  Digoxin therapy: textbooks, theory and practice.

Authors:  J K Aronson; D G Grahame-Smith
Journal:  Br J Clin Pharmacol       Date:  1976-08       Impact factor: 4.335

Review 6.  Disease-related alterations in cardiac glycoside disposition.

Authors:  H R Ochs; D J Greenblatt; G Bodem; H J Dengler
Journal:  Clin Pharmacokinet       Date:  1982 Sep-Oct       Impact factor: 6.447

7.  Overall pharmacokinetics during prolonged treatment of healthy volunteers with digoxin and beta-methyldigoxin.

Authors:  F Keller; H P Blumenthal; K Maertin; N Rietbrock
Journal:  Eur J Clin Pharmacol       Date:  1977-12-16       Impact factor: 2.953

8.  Disposition of beta-methyldigoxin in man.

Authors:  N Rietbrock; U Abshagen; K Bergmann; H Rennekamp
Journal:  Eur J Clin Pharmacol       Date:  1975-12-19       Impact factor: 2.953

Review 9.  Clinical pharmacokinetics of digoxin.

Authors:  E Iisalo
Journal:  Clin Pharmacokinet       Date:  1977 Jan-Feb       Impact factor: 6.447

10.  Comparative studies of the protein binding of digoxin and its metabolites.

Authors:  P H Hinderling
Journal:  Agents Actions       Date:  1977-09
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