Literature DB >> 581101

Jaundice phototherapy: micro flow-cell photometry reveals rapid biliary response of Gunn rats to light.

A F McDonagh, L M Ramonas.   

Abstract

Hepatic pigment clearance in rats can be followed continuously with photometric detectors designed for high-pressure liquid chromatography. This method showed that light has a fast effect on bilirubin metabolism in homozygous Gunn rats, even at low doses and intensities. This is consistent with geometric isomerization of bilirubin IXalpha as a primary step in phototherapy.

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Year:  1978        PMID： 581101     DOI： 10.1126/science.581101

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  4 in total

1.  Demonstration of a geometric isomer of bilirubin-IX alpha in the serum of a hyperbilirubinaemic newborn infant and the mechanism of jaundice phototherapy.

Authors:  S Onishi; K Isobe; S Itoh; N Kawade; S Sugiyama
Journal:  Biochem J       Date:  1980-09-15       Impact factor: 3.857

2.  Photoisomerized bilirubin in blood from infants receiving phototherapy.

Authors:  A A Lamola; W E Blumberg; R McClead; A Fanaroff
Journal:  Proc Natl Acad Sci U S A       Date:  1981-03       Impact factor: 11.205

3.  Kinetics of biliary excretion of the main two bilirubin photoproducts after injection into Gunn rats.

Authors:  S Onishi; N Kawade; S Itoh; K Isobe; S Sugiyama; T Hashimoto; H Narita
Journal:  Biochem J       Date:  1981-07-15       Impact factor: 3.857

4.  Hepatic excretion of circulating bilirubin photoproducts in the Gunn rat.

Authors:  A F McDonagh; L A Palma
Journal:  J Clin Invest       Date:  1980-11       Impact factor: 14.808
  4 in total

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