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Literature DB >> 5810070

The reversibility of the delta8-cholestenol-delta7-cholestenol isomerase reaction in cholesterol biosynthesis.

Abstract

The incubation of Delta(7)-cholestenol with a 10000g supernatant or 105000g microsomes in the presence of tritiated water is studied. The reisolated Delta(7)-cholestenol contained up to 0.67g.atom of tritium/mole. This result can best be explained by assuming the reversibility of the reaction Delta(8)-cholestenol right harpoon over left harpoon Delta(7)-cholestenol.

Entities: Chemical

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Year: 1969 PMID： 5810070 PMCID： PMC1184797 DOI： 10.1042/bj1140071

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

1 in total

1. The biological conversion of 7-dehydrocholesterol into cholesterol and comments on the reduction of double bonds.

Authors: D C Wilton; K A Munday; S J Skinner; M Akhtar
Journal: Biochem J Date: 1968-02 Impact factor: 3.857

1 in total

9 in total

1. Silver ion high pressure liquid chromatography provides unprecedented separation of sterols: application to the enzymatic formation of cholesta-5,8-dien-3 beta-ol.

Authors: B Ruan; J Shey; N Gerst; W K Wilson; G J Schroepfer
Journal: Proc Natl Acad Sci U S A Date: 1996-10-15 Impact factor: 11.205

2. The stereochemistry of hydrogen elimination during 7,8-double bond formation by Tetrahymena pyriformis.

Authors: D C Wilton; M Akhtar
Journal: Biochem J Date: 1970-02 Impact factor: 3.857

3. Different approaches toward an automatic structural alignment of drug molecules: applications to sterol mimics, thrombin and thermolysin inhibitors.

Authors: G Klebe; T Mietzner; F Weber
Journal: J Comput Aided Mol Des Date: 1994-12 Impact factor: 3.686

4. Characterization of plant carotenoid cyclases as members of the flavoprotein family functioning with no net redox change.

Authors: Alexis Samba Mialoundama; Dimitri Heintz; Nurul Jadid; Paul Nkeng; Alain Rahier; Jozsef Deli; Bilal Camara; Florence Bouvier
Journal: Plant Physiol Date: 2010-05-11 Impact factor: 8.340

The reversibility of the delta8-cholestenol-delta7-cholestenol isomerase reaction in cholesterol biosynthesis.

1. The biological conversion of 7-dehydrocholesterol into cholesterol and comments on the reduction of double bonds.

1. Silver ion high pressure liquid chromatography provides unprecedented separation of sterols: application to the enzymatic formation of cholesta-5,8-dien-3 beta-ol.

2. The stereochemistry of hydrogen elimination during 7,8-double bond formation by Tetrahymena pyriformis.

3. Different approaches toward an automatic structural alignment of drug molecules: applications to sterol mimics, thrombin and thermolysin inhibitors.

4. Characterization of plant carotenoid cyclases as members of the flavoprotein family functioning with no net redox change.

5. Crystal structure of isopentenyl diphosphate:dimethylallyl diphosphate isomerase.

6. The stereochemistry of hydrogen elimination from C-7 in cholesterol and ergosterol biosynthesis.

7. Design of high energy intermediate analogues to study sterol biosynthesis in higher plants.

8. TM6SF2 and MAC30, new enzyme homologs in sterol metabolism and common metabolic disease.

9. Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition.