Literature DB >> 576989

Intoxication caused by interaction of chloramphenicol and phenytoin.

J Q Rose, H K Choi, J J Schentag, W R Kinkel, W J Jusko.   

Abstract

A patient with a brain tumor and seizures who was receiving maintenance doses of phenytoin was given chloramphenicol on three occasions. Her neurological status was both complicated and obscured by the reoccurrence of phenytoin intoxication. Retrospective drug analysis showed a marked elevation of serum concentrations of phenytoin during each course of chloramphenicol.

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Year:  1977        PMID: 576989

Source DB:  PubMed          Journal:  JAMA        ISSN: 0098-7484            Impact factor:   56.272


  8 in total

Review 1.  Pharmacokinetic drug interactions with phenytoin (Part II).

Authors:  R L Nation; A M Evans; R W Milne
Journal:  Clin Pharmacokinet       Date:  1990-02       Impact factor: 6.447

2.  Antibiotic-induced neurotoxicity.

Authors:  Shamik Bhattacharyya; Ryan Darby; Aaron L Berkowitz
Journal:  Curr Infect Dis Rep       Date:  2014-12       Impact factor: 3.725

Review 3.  Drug interactions with phenytoin.

Authors:  E Perucca; A Richens
Journal:  Drugs       Date:  1981-02       Impact factor: 9.546

Review 4.  Pharmacokinetic interactions with antiepileptic drugs.

Authors:  E Perucca
Journal:  Clin Pharmacokinet       Date:  1982 Jan-Feb       Impact factor: 6.447

Review 5.  Clinical pharmacokinetics of chloramphenicol and chloramphenicol succinate.

Authors:  P J Ambrose
Journal:  Clin Pharmacokinet       Date:  1984 May-Jun       Impact factor: 6.447

Review 6.  Clinical pharmacokinetic considerations in the treatment of increased intracranial pressure.

Authors:  G Heinemeyer
Journal:  Clin Pharmacokinet       Date:  1987-07       Impact factor: 6.447

7.  Unusual presentation of iatrogenic phenytoin toxicity in a newborn.

Authors:  Jennifer A Lowry; John C Vandover; Jan DeGreeff; Anthony J Scalzo
Journal:  J Med Toxicol       Date:  2005-12

8.  Chloramphenicol is a potent inhibitor of cytochrome P450 isoforms CYP2C19 and CYP3A4 in human liver microsomes.

Authors:  Ji-Young Park; Kyoung-Ah Kim; Su-Lyun Kim
Journal:  Antimicrob Agents Chemother       Date:  2003-11       Impact factor: 5.191

  8 in total

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