Literature DB >> 5763493

Macroglobulin structure: homology of mu and gamma heavy chains of human immunoglobulins.

M Wikler, H Köhler, T Shinoda, F W Putnam.   

Abstract

The amino acid sequence of fragments obtained by cyanogen bromide cleavage of the mu-chain of a human gammaM-globulin is homologous to the NH(2)-terminal sequences of the gamma-chain of human and rabbit gammaG-globulins and is related to that of human light chains. This supports the hypothesis that light and heavy chains evolved from a common ancestral gene.

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Year:  1969        PMID： 5763493     DOI： 10.1126/science.163.3862.75

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  18 in total

Review 1.  Immunoglobulins.

Authors:  J Bradley
Journal:  J Med Genet       Date:  1974-03       Impact factor: 6.318

2.  Variable region sequences of five human immunoglobulin heavy chains of the VH3 subgroup: definitive identification of four heavy chain hypervariable regions.

Authors:  J D Capra; J M Kehoe
Journal:  Proc Natl Acad Sci U S A       Date:  1974-03       Impact factor: 11.205

3.  Prolonged adjuvant stimulation in germ-free BALB-c mice: development of plasma cell neoplasia.

Authors:  K R McIntire; G L Princler
Journal:  Immunology       Date:  1969-09       Impact factor: 7.397

4.  On the homologous relationship between the variable and the constant parts of immunoglobulins.

Authors:  J Urbain
Journal:  Biochem Genet       Date:  1972-04       Impact factor: 1.890

5.  Subgroups of amino acid sequences in the variable regions of immunoglobulin heavy chains.

Authors:  B A Cunningham; M N Pflumm; U Rutishauser; G M Edelman
Journal:  Proc Natl Acad Sci U S A       Date:  1969-11       Impact factor: 11.205

6.  The covalent structure of an entire gammaG immunoglobulin molecule.

Authors:  G M Edelman; B A Cunningham; W E Gall; P D Gottlieb; U Rutishauser; M J Waxdal
Journal:  Proc Natl Acad Sci U S A       Date:  1969-05       Impact factor: 11.205

Review 7.  Genetic determination of antibody specificity. Gene translocation and fusion, the molecular basis for the differentiation of the antibody-producing cell.

Authors:  N Hilschmann; H U Barnikol; H Kratzin; P Altevogt; M Engelhard; S Barnikol-Watanabe
Journal:  Naturwissenschaften       Date:  1978-12

8.  Attachment of carbohydrate to the variable region of myeloma immunoglobulin light chains.

Authors:  H C Sox; L Hood
Journal:  Proc Natl Acad Sci U S A       Date:  1970-07       Impact factor: 11.205

9.  Evidence for multiple gene control of a single polypeptide chain: the heavy chain of rabbit immunoglobulin.

Authors:  M E Koshland; J J Davis; N J Fujita
Journal:  Proc Natl Acad Sci U S A       Date:  1969-08       Impact factor: 11.205

10.  Anti-antibody activity of a monoclonal macroglobulin.

Authors:  N L Warner; M R Mackenzie; H H Fudenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1971-11       Impact factor: 11.205
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