Literature DB >> 4193390

Attachment of carbohydrate to the variable region of myeloma immunoglobulin light chains.

H C Sox, L Hood.   

Abstract

Approximately 15 per cent of the light chains from homogeneous immunoglobulins in patients with multiple myeloma contain an oligosaccharide group. Five human myeloma light chains that contained carbohydrate were studied. The sequence Asn-[unk]-Ser/Thr was at the site of carbohydrate attachment in all light chains. The carbohydrate group was attached to the asparagine residue of this triplet sequence which in all five light chains was located in the variable region. The occasional occurrence of carbohydrate in myeloma light chains is seen as the consequence of a variable region mutation creating an Asn-[unk]-Ser/Thr sequence to which carbohydrate is attached by an enzyme capable of recognizing the characteristic triplet sequence.

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Year:  1970        PMID： 4193390      PMCID： PMC283146          DOI： 10.1073/pnas.66.3.975

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  19 in total

1.  Comparative analysis of the IgG heavy chain carbohydrate peptide.

Authors:  J W Howell; L Hood; B G Sanders
Journal:  J Mol Biol       Date:  1967-12-28       Impact factor: 5.469

2.  [The complete amino acid sequence of Bence Jones protein New (lambda-type). Subgroups in the variable part of immunoglobulin L-chains of the lambda-type].

Authors:  B Langer; M Steinmetz-Kayne; N Hilschmann
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1968-07

3.  The carbohydrate contents of fragments and polypeptide chains of human gamma-G-myeloma proteins of different heavy-chain subclasses.

Authors:  C A Abel; H L Spiegelberg; H M Grey
Journal:  Biochemistry       Date:  1968-04       Impact factor: 3.162

4.  The attachment site of carbohydrate in a mouse immunoglobulin light chain.

Authors:  F Melchers
Journal:  Biochemistry       Date:  1969-03       Impact factor: 3.162

5.  Characterization of human L type Bence-Jones proteins containing carbohydrate.

Authors:  A B Edmundson; F A Sheber; K R Ely; N B Simonds; N K Hutson; J L Rossiter
Journal:  Arch Biochem Biophys       Date:  1968-09-20       Impact factor: 4.013

Review 6.  On the biological role of glycoproteins.

Authors:  E H Eylar
Journal:  J Theor Biol       Date:  1966-01       Impact factor: 2.691

7.  Macroglobulin structure: homology of mu and gamma heavy chains of human immunoglobulins.

Authors:  M Wikler; H Köhler; T Shinoda; F W Putnam
Journal:  Science       Date:  1969-01-03       Impact factor: 47.728

8.  [Chemical structure of 2 kappa-type Bence Jones proteins (Roy and Cum.)].

Authors:  N Hilschmann
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1967-08

9.  Separation of dansyl-amino acids by polyamide layer chromatography.

Authors:  K R Woods; K T Wang
Journal:  Biochim Biophys Acta       Date:  1967-02-21

10.  On the aminoethylation of proteins.

Authors:  M A Raftery; R D Cole
Journal:  J Biol Chem       Date:  1966-08-10       Impact factor: 5.157
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  28 in total

1.  Altered reactivity of immunoglobulin produced by human-human hybridoma cells transfected by pSV2-neo gene.

Authors:  H Tachibana; K Akiyama; S Shirahata; H Murakami
Journal:  Cytotechnology       Date:  1991-07       Impact factor: 2.058

2.  Building high affinity human antibodies by altering the glycosylation on the light chain variable region in N-acetylglucosamine-supplemented hybridoma cultures.

Authors:  H Tachibana; J Y Kim; S Shirahata
Journal:  Cytotechnology       Date:  1997-01       Impact factor: 2.058

3.  Extensive homology between the subunits of the phytohemagglutinin mitogenic proteins derived from Phaseolus vulgaris.

Authors:  J B Miller; R Hsu; R Heinrikson; S Yachnin
Journal:  Proc Natl Acad Sci U S A       Date:  1975-04       Impact factor: 11.205

4.  Aberrant immunoglobulin synthesis in light chain amyloidosis. Free light chain and light chain fragment production by human bone marrow cells in short-term tissue culture.

Authors:  J Buxbaum
Journal:  J Clin Invest       Date:  1986-09       Impact factor: 14.808

5.  Structure of a monoclonal kappa chain of the V kappa IV subgroup in the kidney and plasma cells in light chain deposition disease.

Authors:  M Cogné; J L Preud'homme; M Bauwens; G Touchard; P Aucouturier
Journal:  J Clin Invest       Date:  1991-06       Impact factor: 14.808

Review 6.  Antibody variable region glycosylation: biochemical and clinical effects.

Authors:  A Wright; S L Morrison
Journal:  Springer Semin Immunopathol       Date:  1993

7.  Modified antigen-binding of human antibodies with glycosylation variations of the light chains produced in sugar-limited human hybridoma cultures.

Authors:  H Tachibana; K Jiyoun; K Taniguchi; Y Ushio; K Teruya; K Osada; Y Inoue; S Shirahata; H Murakami
Journal:  In Vitro Cell Dev Biol Anim       Date:  1996-03       Impact factor: 2.416

8.  Structural studies of a carbohydrate-containing immunoglobulin-lambda-light-chain amyloid-fibril protein (AL) of variable subgroup III.

Authors:  E Holm; K Sletten; G Husby
Journal:  Biochem J       Date:  1986-11-01       Impact factor: 3.857

9.  The amino acid sequence of a carbohydrate-containing immunoglobulin-light-chain-type amyloid-fibril protein.

Authors:  T Tveteraas; K Sletten; P Westermark
Journal:  Biochem J       Date:  1985-11-15       Impact factor: 3.857

10.  Primary structure of a deleted human lambda type immunoglobulin light chain containing carbohydrate: protein Sm lambda.

Authors:  F A Garver; L Chang; J Mendicino; T Isobe; E F Osserman
Journal:  Proc Natl Acad Sci U S A       Date:  1975-11       Impact factor: 11.205
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