Literature DB >> 575199

Chronic treatment with antidepressant drugs: potentiation of apomorphine-induced aggressive behaviour in rats.

J Maj, E Mogilnicka, A Kordecka.   

Abstract

Chronic (14 days) but not acute treatment with antidepressants (amitriptyline, imipramine, desipramine, clomipramine, mianserin, danitracen, iprindole) potentiated the aggressive behaviour induced by apomorphine (APO) in rats. The APO stereotypy was not changed. A similar potentiation was caused by chronic treatment with phentolamine or thioridazine but not with spiperone or deazepam. In rats treated chronically with amitriptyline the APO-induced fighting was antagonized by phenoxybenzamine or spiperone, and not by metergoline. The results allows us to postulate that the chronic treatment with antidepressants potentiates the APO-induced aggressiveness via the noradrenergic mechanism, i.e., through an enhanced response to the endogenous NA.

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Year:  1979        PMID： 575199     DOI： 10.1016/0304-3940(79)91516-7

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  10 in total

Review 1.  Psychopharmacological properties of calcium channel inhibitors.

Authors:  O Pucilowski
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

2.  The responsiveness of cerebral cortical adrenergic receptors after chronic administration of atypical antidepressant mianserin.

Authors:  I Nalepa; J Vetulani
Journal:  J Psychiatry Neurosci       Date:  1994-03       Impact factor: 6.186

3.  Chlorimipramine, electroconvulsive shock and combination thereof: differential effects of chronic treatment on apomorphine-induced behaviours and on striatal and mesocortical dopamine turnover.

Authors:  C Spyraki; Z Papadopoulou; A Kourkoubas; D Varonos
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-04       Impact factor: 3.000

4.  Repeated treatment with antidepressant drugs increases the behavioural response to apomorphine.

Authors:  J Maj; Z Rogóz; G Skuza; H Sowińska
Journal:  J Neural Transm       Date:  1984       Impact factor: 3.575

5.  Use of potentiation of thyrotrophin releasing hormone (TRH)-induced hyperthermia as a test for screening antidepressants which activate alpha-adrenoceptor systems.

Authors:  M Desiles; R Rips
Journal:  Br J Pharmacol       Date:  1981-09       Impact factor: 8.739

6.  Effects of chronic treatment with antidepressants on aggressiveness induced by clonidine in mice.

Authors:  J Maj; Z Rogóz; G Skuza; H Sowińska
Journal:  J Neural Transm       Date:  1982       Impact factor: 3.575

7.  Repeated treatment with imipramine potentiates the locomotor effect of apomorphine administered into the hippocampus in rats.

Authors:  A Smiałowski; J Maj
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

8.  Effects of chronic antidepressant treatment on dopamine-related [3H]SCH 23390 and [3H]spiperone binding in the rat striatum.

Authors:  P R Paetsch; A J Greenshaw
Journal:  Cell Mol Neurobiol       Date:  1992-12       Impact factor: 5.046

9.  Chronic treatment with imipramine: further functional evidence for the enhanced noradrenergic transmission in flexor reflex activity.

Authors:  J Maj; Z Górka; M Melzacka; A Rawłów; A Pilc
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-05       Impact factor: 3.000

10.  Chronic treatment with antidepressants: protentiation of clonidine-induced aggression in mice via noradrenergic mechanism.

Authors:  J Maj; E Mogilnicka; V Klimek; A Kordecka-Magiera
Journal:  J Neural Transm       Date:  1981       Impact factor: 3.575
  10 in total

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