Literature DB >> 1490276

Effects of chronic antidepressant treatment on dopamine-related [3H]SCH 23390 and [3H]spiperone binding in the rat striatum.

P R Paetsch1, A J Greenshaw.   

Abstract

1. The effects of chronic administration of antidepressants on dopamine-related [3H]SCH 23390 and [3H]spiperone binding to rat striatal membranes were assessed. 2. The monoamine oxidase inhibitors phenelzine (5 or 10 mg kg-1/day) and tranylcypromine (1 mg kg-1/day) and the tricyclic desipramine (10 mg kg-1/day) were administered for 28 days by constant subcutaneous infusion using Alzet (2ML4) osmotic minipumps. 3. These treatments did not alter Kd estimates for either [3H]SCH 23390 or [3H]spiperone binding sites. The monoamine oxidase inhibitors induced a decrease in the Bmax values for both [3H]SCH 23990 and [3H]spiperone binding sites. Desipramine induced a decrease in the Bmax value for [3H]SCH 23390 binding but had no effect on the Bmax value for [3H]spiperone binding.

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Year:  1992        PMID： 1490276     DOI： 10.1007/bf00711239

Source DB:  PubMed          Journal:  Cell Mol Neurobiol        ISSN： 0272-4340            Impact factor:   5.046


  44 in total

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Authors:  M Tiberi; K R Jarvie; C Silvia; P Falardeau; J A Gingrich; N Godinot; L Bertrand; T L Yang-Feng; R T Fremeau; M G Caron
Journal:  Proc Natl Acad Sci U S A       Date:  1991-09-01       Impact factor: 11.205

Review 2.  Molecular biology of the dopamine receptors.

Authors:  O Civelli; J R Bunzow; D K Grandy; Q Y Zhou; H H Van Tol
Journal:  Eur J Pharmacol       Date:  1991-08-14       Impact factor: 4.432

3.  Osmotic mini-pumps: a convenient program for weight-adjusted filling concentrations.

Authors:  A J Greenshaw
Journal:  Brain Res Bull       Date:  1986-05       Impact factor: 4.077

4.  Cloning and expression of a rat D2 dopamine receptor cDNA.

Authors:  J R Bunzow; H H Van Tol; D K Grandy; P Albert; J Salon; M Christie; C A Machida; K A Neve; O Civelli
Journal:  Nature       Date:  1988 Dec 22-29       Impact factor: 49.962

Review 5.  Dopamine receptor subtypes: beyond the D1/D2 classification.

Authors:  P H Andersen; J A Gingrich; M D Bates; A Dearry; P Falardeau; S E Senogles; M G Caron
Journal:  Trends Pharmacol Sci       Date:  1990-06       Impact factor: 14.819

6.  In vivo neurochemical effects of electroconvulsive shock studied by microdialysis in the rat striatum.

Authors:  A P Zis; G G Nomikos; G Damsma; H C Fibiger
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

7.  Molecular cloning and expression of a D1 dopamine receptor linked to adenylyl cyclase activation.

Authors:  F J Monsma; L C Mahan; L D McVittie; C R Gerfen; D R Sibley
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

Review 8.  Dopamine and depression: a review of recent evidence. I. Empirical studies.

Authors:  P Willner
Journal:  Brain Res       Date:  1983-12       Impact factor: 3.252

9.  Binding of 3H-spiperone and 3H-(-)-sulpiride to dopamine D2 receptors in rat striatal membranes: methodological considerations and demonstration of the identical nature of the binding sites for the two ligands.

Authors:  S Urwyler; D Coward
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-02       Impact factor: 3.000

10.  Upregulation of gamma-aminobutyric acid (GABA) B binding sites in rat frontal cortex: a common action of repeated administration of different classes of antidepressants and electroshock.

Authors:  K G Lloyd; F Thuret; A Pilc
Journal:  J Pharmacol Exp Ther       Date:  1985-10       Impact factor: 4.030
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  5 in total

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Authors:  Helge Frieling; Stefan Bleich
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2006-08       Impact factor: 5.270

2.  Unchanged density of caudate nucleus dopamine uptake sites in depressed suicide victims.

Authors:  P Allard; M Norlén
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

3.  D1 receptor binding in rat striatum: modification by various D1 and D2 antagonists, but not by sibutramine hydrochloride, antidepressants or treatments which enhance central dopaminergic function.

Authors:  S C Cheetham; C J Kettle; K F Martin; D J Heal
Journal:  J Neural Transm Gen Sect       Date:  1995

4.  Down-regulation of beta-adrenergic and dopaminergic receptors induced by 2-phenylethylamine.

Authors:  P R Paetsch; A J Greenshaw
Journal:  Cell Mol Neurobiol       Date:  1993-06       Impact factor: 5.046

Review 5.  2-Phenylethylamine-induced changes in catecholamine receptor density: implications for antidepressant drug action.

Authors:  P R Paetsch; A J Greenshaw
Journal:  Neurochem Res       Date:  1993-09       Impact factor: 3.996
  5 in total

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