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Literature DB >> 574357

Human male infertility, probably genetically determined, due to defective meiosis and spermatogenic arrest.

Abstract

A family is reported in which infertility affected three men related through their mothers. The propositus, from testicular tissue was obtained, exhibited desynapsis, lack of chiasmata, and degeneration of spermatocytes during the first meiotic division. These observations lead us to postulate that a gene for meiotic disturbance, spermatogenic arrest, and azoospermia is segregating in this family; its mode of inheritance conforms to either an X-linked recessive or a sex-limited autosomal dominant transmission.

Entities: Disease Species

Mesh：

Year: 1979 PMID： 574357 PMCID： PMC1685902

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

13 in total

1. Biochemical analysis of meiosis in the male mouse. II. DNA metabolism at pachytene.

Authors: Y Hotta; A C Chandley; H Stern
Journal: Chromosoma Date: 1977-07-08 Impact factor: 4.316

2. Biochemical analysis of meiosis in the male mouse. I. Separation of DNA labelling of specific spermatogenic stages.

Authors: A C Chandley; Y Hotta; H Stern
Journal: Chromosoma Date: 1977-07-08 Impact factor: 4.316

Review 3. Human disorders showing increased sensitivity to the induction of genetic damage.

Authors: C F Arlett; A R Lehmann
Journal: Annu Rev Genet Date: 1978 Impact factor: 16.830

Review 4. Biochemical controls of meiosis.

Authors: H Stern; Y Hotta
Journal: Annu Rev Genet Date: 1973 Impact factor: 16.830

5. Bare-patches, a new sex-linked gene in the mouse, associated with a high production of XO females. I. A preliminary report of breeding experiments.

Authors: R J Phillips; S G Hawker; H J Moseley
Journal: Genet Res Date: 1973-08 Impact factor: 1.588

6. Abnormal synaptonemal complex in an oligochiasmatic man with spermatogenic arrest.

Authors: M Hultén; A J Solari; N E Skakkebaek
Journal: Hereditas Date: 1974 Impact factor: 3.271

7. Normal chiasma formation in a male with xeroderma pigmentosum.

Authors: M Hultén; D Weerd-Kastelein; D Bootsma; A J Solari; N E Skakkebaek; G Swanbeck
Journal: Hereditas Date: 1974 Impact factor: 3.271

8. Studies on repair of adenovirus 2 by human fibroblasts using normal, xeroderma pigmentosum, and xeroderma pigmentosum heterozygous strains.

Authors: R S Day
Journal: Cancer Res Date: 1974-08 Impact factor: 12.701

9. Spontaneous univalence at male meiosis in the mouse.

Authors: D J Purnell
Journal: Cytogenet Cell Genet Date: 1973

Review 10. The genetic control of meiosis.

Authors: B S Baker; A T Carpenter; M S Esposito; R E Esposito; L Sandler
Journal: Annu Rev Genet Date: 1976 Impact factor: 16.830

9 in total

1. A dominant-negative pleiotrophin mutant introduced by homologous recombination leads to germ-cell apoptosis in male mice.

Authors: N Zhang; H J Yeh; R Zhong; Y S Li; T F Deuel
Journal: Proc Natl Acad Sci U S A Date: 1999-06-08 Impact factor: 11.205

2. Meiotic arrest at first spermatocyte level: a new inherited infertility disorder.

Authors: J M Cantú; F Rivas; P Hernández-Jáuregui; M Díaz; V Cortés-Gallegos; G Vaca; A Velázquez; B Ibarra
Journal: Hum Genet Date: 1981 Impact factor: 4.132

3. Comments on some genetic abnormalities of sex determination and sex differentiation in Homo sapiens.

Authors: J M Opitz
Journal: Eur J Pediatr Date: 1980-03 Impact factor: 3.183

Review 4. Localisation of male determining factors in man: a thorough review of structural anomalies of the Y chromosome.

Authors: R M Davis
Journal: J Med Genet Date: 1981-06 Impact factor: 6.318