Literature DB >> 569630

Epithelial rat liver cells have cell surface receptors recognizing a phosphorylated carbohydrate on lysosomal enzymes.

K Ullrich, G Mersmann, M Fleischer, K von Figura.   

Abstract

Receptor-mediated endocytosis of alpha-N-acetylglucosaminidase by cultured epithelial rat liver cells is inhibited by mannose, L-fucose and most effectively by mannose 6-phosphate. Endocytosis of alpha-N-acetylglucosaminidase is lost after treatment of the enzyme with alkaline phosphatase. These findings indicate that epithelial rat liver cells possess cell surface receptors that recognize a phosphorylated carbohydrate on alpha-N-acetylglucosaminidase, as was previously reported for cell surface receptors of human skin fibroblasts. Inhibition of alpha-mannosidase endocytosis by epithelial rat liver cells in the presence of mannose 6-phosphate and loss of enzyme endocytosis after treatment with alkaline phosphatase suggest that this enzyme is recognized by the same receptor.

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Year:  1978        PMID： 569630     DOI： 10.1515/bchm2.1978.359.2.1591

Source DB:  PubMed          Journal:  Hoppe Seylers Z Physiol Chem        ISSN： 0018-4888


  9 in total

1.  Recognition of human urine alpha-N-acetylglucosaminidase by rat hepatocytes. Involvement of receptors specific for galactose, mannose 6-phosphate and mannose.

Authors:  K Ullrich; R Basner; V Gieselmann; K Von Figura
Journal:  Biochem J       Date:  1979-05-15       Impact factor: 3.857

2.  Characterization of a membrane-associated receptor from bovine liver that binds phosphomannosyl residues of bovine testicular beta-galactosidase.

Authors:  G G Sahagian; J Distler; G W Jourdian
Journal:  Proc Natl Acad Sci U S A       Date:  1981-07       Impact factor: 11.205

3.  Analysis of lectin-dependent recognition of desialylated erythrocytes by Kupffer cells.

Authors:  J Schlepper-Schäfer; V Kolb-Bachofen; H Kolb
Journal:  Biochem J       Date:  1980-03-15       Impact factor: 3.857

4.  Endocytosis of lysosomal enzymes by non-parenchymal rat liver cells. Comparative study of lysosomal-enzyme uptake by hepatocytes and non-parenchymal liver cells.

Authors:  K Ullrich; V Gieselmann; G Mersmann; K Von Figura
Journal:  Biochem J       Date:  1979-08-15       Impact factor: 3.857

5.  Endocytosis of beta-N-acetylglucosaminidase from sections of mucolipidosis-II and-III fibroblasts by non-parenchymal rat liver cells.

Authors:  K Ullrich; K von Figura
Journal:  Biochem J       Date:  1979-07-15       Impact factor: 3.857

Review 6.  Mechanisms of metal--salt methods in enzyme cytochemistry with special reference to acid phosphatase.

Authors:  A S De Jong
Journal:  Histochem J       Date:  1982-01

7.  Normal exocytosis and endocytosis of lysosomal beta-hexosaminidase in a case of alpha 1-antitrypsin deficiency.

Authors:  K Ullrich
Journal:  Klin Wochenschr       Date:  1983-03-15

8.  Regulation of heparan sulphate metabolism by adenosine 3':5'-cyclic monophosphate in hepatocytes in culture.

Authors:  P R Sudhakaran; W Sinn; K von Figura
Journal:  Biochem J       Date:  1980-11-15       Impact factor: 3.857

9.  Ultrastructural localization of the mannose 6-phosphate receptor in rat liver.

Authors:  H J Geuze; J W Slot; G J Strous; A Hasilik; K Von Figura
Journal:  J Cell Biol       Date:  1984-06       Impact factor: 10.539
  9 in total

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