| Literature DB >> 496912 |
Abstract
beta-N-Acetylglucosaminidase isolated from the secretions of fibroblasts of mucolipidosis-II and -III patients is internalized by cultured non-parenchymal rat liver cells. The rate of endocytosis compared with that of beta-N-acetylglucosaminidase from control fibroblasts was 11 and 19% for the enzyme from mucolipidosis-II and -III patients respectively. The inhibition of endocytosis by mannan indicates that the beta-N-acetylglucosaminidase from mucolipidosis-II and -III patients is recognized by cell-surface receptors specific for mannose.Entities:
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Year: 1979 PMID: 496912 PMCID: PMC1161256 DOI: 10.1042/bj1820245
Source DB: PubMed Journal: Biochem J ISSN: 0264-6021 Impact factor: 3.857