Literature DB >> 564220

The effect of baclofen on alpha-flupenthixol-induced catalepsy in the rat.

J A Davies, J Williams.   

Abstract

1 alpha-Flupenthixol (alpha-FPT; 0.2 mg/kg i.p.) when administered to rats produced catalepsy. 2 Baclofen (10 mg/kg i.p.) given 30 min after alpha-FPT had a biphasic effect on the catalepsy. Initially there was a potentiation of the effect, followed by a significant attenuation of the degree of catalepsy. 3 Possible mechanisms of action are discussed.

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Year:  1978        PMID： 564220      PMCID： PMC1667811          DOI： 10.1111/j.1476-5381.1978.tb08460.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

1.  Evidence for an inhibitory gabergic control of the meso-limbic dopamine neurons: possibility of improving treatment of schizophrenia by combined treatment with neuroleptics and gabergic drugs.

Authors:  K Fuxe; T Hökfelt; A Ljungdahl; L Agnati; O Johansson; M Perez de la Mora
Journal:  Med Biol       Date:  1975-06

2.  EFFECT OF CHLORPROMAZINE OR HALOPERIDOL ON FORMATION OF 3METHOXYTYRAMINE AND NORMETANEPHRINE IN MOUSE BRAIN.

Authors:  A CARLSSON; M LINDQVIST
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1963

Review 3.  Possible involvement of GABA in the central actions of benzodiazepines.

Authors:  W Haefely; A Kulcsár; H Möhler; L Pieri; P Polc; R Schaffner
Journal:  Adv Biochem Psychopharmacol       Date:  1975

4.  The importance of the ascending dopaminergic systems to the extrapyramidal and mesolimbic brain areas for the cataleptic action of the neuroleptic and cholinergic agents.

Authors:  B Costall; R J Naylor
Journal:  Neuropharmacology       Date:  1974-05       Impact factor: 5.250

5.  The comparative pharmacology of flupenthixol and some reference neuroleptics.

Authors:  I M Nielsen; V Pedersen; M Nymark; K F Franck; V Boeck; B Fjalland; A V Christensen
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1973

6.  Role of -aminobutyric acid (GABA) in the extrapyramidal motor system. 2. Some evidence for the existence of a type of GABA-rich strio-nigral neurons.

Authors:  J S Kim; I J Bak; R Hassler; Y Okada
Journal:  Exp Brain Res       Date:  1971       Impact factor: 1.972

7.  The significance of dopamine-receptor blockade for the mechanism of action of neuroleptic drugs.

Authors:  J M van Rossum
Journal:  Arch Int Pharmacodyn Ther       Date:  1966-04

8.  Interaction of benzodiazepines with neuroleptics at central dopamine neurons.

Authors:  H H Keller; R Schaffner; W Haefely
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976-07       Impact factor: 3.000

9.  Increase in mouse brain dopamine content by baclofen: effects of apomorphine and neuroleptics.

Authors:  G Gianutsos; K E Moore
Journal:  Psychopharmacology (Berl)       Date:  1977-05-09       Impact factor: 4.530
  9 in total
  1 in total

1.  The action of DL-2,4-diaminobutyric acid on the cataleptogenic effects of pilocarpine and alpha-flupenthixol in rats.

Authors:  J Williams; J A Davies
Journal:  Psychopharmacology (Berl)       Date:  1979-06-28       Impact factor: 4.530
  1 in total

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