Literature DB >> 113836

The action of DL-2,4-diaminobutyric acid on the cataleptogenic effects of pilocarpine and alpha-flupenthixol in rats.

J Williams, J A Davies.   

Abstract

The existence of a strionigral GABA-ergic pathway having an inhibitory effect on the nigrostriatal dopaminergic system has been proposed. The work reported in this paper was undertaken to investigate whether modification of the GABA-eric system by the GABA neuronal uptake inhibitor DL-2,4-diaminobutyric acid (DABA) would affect cholinergic (pilocarpine) and/or neuroleptic alpha-flupenthixol (alpha-FPT) induced catalepsy. DABA pretreatment was shown to enhance significantly both alpha-FPT and pilocarpine induced catalepsy. DABA alone had no cataleptic activity. The results are interpreted as supporting the existence of an inhibitory strionigral GABA-ergic pathway.

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Year:  1979        PMID： 113836     DOI： 10.1007/bf00427349

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  14 in total

1.  Fine structural synaptic organization of the corpus striatum and substantia nigra in rat and cat.

Authors:  I J Bak; W B Choi; R Hassler; K G Usunoff; A Wagner
Journal:  Adv Neurol       Date:  1975

2.  EFFECT OF CHLORPROMAZINE OR HALOPERIDOL ON FORMATION OF 3METHOXYTYRAMINE AND NORMETANEPHRINE IN MOUSE BRAIN.

Authors:  A CARLSSON; M LINDQVIST
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1963

3.  The importance of the ascending dopaminergic systems to the extrapyramidal and mesolimbic brain areas for the cataleptic action of the neuroleptic and cholinergic agents.

Authors:  B Costall; R J Naylor
Journal:  Neuropharmacology       Date:  1974-05       Impact factor: 5.250

4.  Interaction between cholinergic and catecholaminergic neurones in rat brain.

Authors:  H Corrodi; K Fuxe; P Lidbrink
Journal:  Brain Res       Date:  1972-08-25       Impact factor: 3.252

5.  Role of -aminobutyric acid (GABA) in the extrapyramidal motor system. 2. Some evidence for the existence of a type of GABA-rich strio-nigral neurons.

Authors:  J S Kim; I J Bak; R Hassler; Y Okada
Journal:  Exp Brain Res       Date:  1971       Impact factor: 1.972

6.  Analysis of local cholinergic tremor mechanisms following selective neurochemical lesions.

Authors:  P M Lalley; G V Rossi; W W Baker
Journal:  Exp Neurol       Date:  1970-05       Impact factor: 5.330

7.  Effects of GABAergic drugs on the catalepsy, striatal homovanillic acid increase and antinociception caused by pilocarpine in rats.

Authors:  I Kääriäinen
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1977-01

8.  The 'neurotoxicity' of L-2,4-diaminobutyric acid.

Authors:  R M O'Neal; C H Chen; C S Reynolds; S K Meghal; R E Koeppe
Journal:  Biochem J       Date:  1968-02       Impact factor: 3.857

9.  The selective blockade by diaminobutyric acid of neuronal uptake of (3H)GABA in rat brain in vivo.

Authors:  I Sutton; M A Simmonds
Journal:  J Neurochem       Date:  1974-07       Impact factor: 5.372

10.  The effect of baclofen on alpha-flupenthixol-induced catalepsy in the rat.

Authors:  J A Davies; J Williams
Journal:  Br J Pharmacol       Date:  1978-02       Impact factor: 8.739
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  2 in total

1.  Effects of growth conditions on the production of neurotoxin 2,4-diaminobutyric acid (DAB) in Microcystis aeruginosa and its universal presence in diverse cyanobacteria isolated from freshwater in China.

Authors:  Hua Fan; Jiangbing Qiu; Lin Fan; Aifeng Li
Journal:  Environ Sci Pollut Res Int       Date:  2014-10-30       Impact factor: 4.223

2.  A role for 5-hydroxytryptamine in the GABA-mimetic potentiation of alpha-flupenthixol-induced catalepsy in the rat.

Authors:  J A Davies; J Williams
Journal:  Br J Pharmacol       Date:  1983-01       Impact factor: 8.739
  2 in total

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