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Literature DB >> 406622

Increase in mouse brain dopamine content by baclofen: effects of apomorphine and neuroleptics.

Abstract

Baclofen, like gamma-butyrolactone, causes a dose-dependent increase in the concentration of dopamine in the mouse brain without affecting the content of norepinephrine. This increase is antagonized by apomorphine. Haloperidol but not pimozide counteracts this effect of apomorphine and dose-dependently enhances the increase in brain dopamine produced by baclofen. The results suggest that baclofen reduces impulse flow in dopaminergic neurons in a manner similar to that produced by gamma-butyrolactone.

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Year: 1977 PMID： 406622 DOI： 10.1007/bf00426702

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

14 in total

1. Synaptic mechanisms in the substantia nigra.

Authors: A Dray; D W Straughan
Journal: J Pharm Pharmacol Date: 1976-04 Impact factor: 3.765

2. Evidence for an inhibitory gabergic control of the meso-limbic dopamine neurons: possibility of improving treatment of schizophrenia by combined treatment with neuroleptics and gabergic drugs.

Authors: K Fuxe; T Hökfelt; A Ljungdahl; L Agnati; O Johansson; M Perez de la Mora
Journal: Med Biol Date: 1975-06

3. A SENSITIVE METHOD FOR SPECTROPHOTOFLUOROMETRIC ASSAY OF CATECHOLAMINES.

Authors: C C CHANG
Journal: Int J Neuropharmacol Date: 1964-12

4. Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity.

Authors: B S Bunney; J R Walters; R H Roth; G K Aghajanian
Journal: J Pharmacol Exp Ther Date: 1973-06 Impact factor: 4.030

5. Evidence for a receptor-mediated feedback control of striatal tyrosine hydroxylase activity.

Authors: W Kehr; A Carlsson; M Lindqvist; T Magnusson; C Atack
Journal: J Pharm Pharmacol Date: 1972-09 Impact factor: 3.765

6. Evidence for dopamine receptor stimulation by apomorphine.

Authors: N E Andén; A Rubenson; K Fuxe; T Hökfelt
Journal: J Pharm Pharmacol Date: 1967-09 Impact factor: 3.765

7. Dopaminergic neurons: similar biochemical and histochemical effects of gamma-hydroxybutyrate and acute lesions of the nigro-neostriatal pathway.

Authors: J R Walters; R H Roth; G K Aghajanian
Journal: J Pharmacol Exp Ther Date: 1973-09 Impact factor: 4.030

8. The influence of 1-hydroxy-3-amino pyrrolidinone-2 (HA-966) on dopamine metabolism in the corpus striatum.

Authors: F C Hillen; E L Noach
Journal: Eur J Pharmacol Date: 1971-10 Impact factor: 4.432

9. Dopaminergic neurons: drug-induced antagonism of the increase in tyrosine hydroxylase activity produced by cessation of impulse flow.

Authors: J R Walters; R H Roth
Journal: J Pharmacol Exp Ther Date: 1974-10 Impact factor: 4.030

10. Differential actions of dopamine agonists and antagonists on the gamma-butyrolactone-induced in mouse brain dopamine.

Authors: G Gianutsos; J E Thornburg; K E Moore
Journal: Psychopharmacology (Berl) Date: 1976-11-24 Impact factor: 4.530

6 in total

5. Effects of intranigral administration of dopamine agonists and antagonists and baclofen on concentrations of dopac and dopamine in the striatum and substantia nigra of the rat.

Authors: S M Wuerthele; N M Friedle; K E Moore
Journal: J Neural Transm Date: 1979 Impact factor: 3.575

Review 6. A Review of the Potential Mechanisms of Action of Baclofen in Alcohol Use Disorder.

Authors: Renaud de Beaurepaire
Journal: Front Psychiatry Date: 2018-10-17 Impact factor: 4.157