Literature DB >> 563989

Radioimmunoassay of enkephalins. Regional distribution in rat brain after morphine treatment and hypophysectomy.

D Wesche, V Höllt, A Herz.   

Abstract

Using highly sensitive and highly specific antisera methionine- and leucine-enkephalin levels were determined in various areas of the rat brain. The highest content of both enkephalins was found in the striatum and the hypothalamus, whereas in the hippocampus, the cerebellum and the cortex only a low content was present. The ratio methionine-enkephalin/leucine-enkephalin was about three. Neither acute or chronic morphine treatment nor precipitated morphine withdrawal induced significant changes in enkephalin levels in any brain region. Also hypophysectomy did not affect the enkephalin content of the various brain regions.

Entities:  

Mesh：

Substances：

Year:  1977        PMID： 563989     DOI： 10.1007/bf00501267

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  12 in total

1.  Opioid peptide enkephalin: immunohistochemical mapping in rat central nervous system.

Authors:  R Simantov; M J Kuhar; G R Uhl; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1977-05       Impact factor: 11.205

2.  Failure of hypophysectomy to alter brain content of opioid peptides (endorphins).

Authors:  A L Cheung; A Goldstein
Journal:  Life Sci       Date:  1976-10-01       Impact factor: 5.037

3.  Elevated levels of enkephalin in morphine-dependent rats.

Authors:  R Simantov; S H Snyder
Journal:  Nature       Date:  1976-08-05       Impact factor: 49.962

4.  Opioid peptides endorphins in pituitary and brain.

Authors:  A Goldstein
Journal:  Science       Date:  1976-09-17       Impact factor: 47.728

5.  Radioimmunoassay of cyclic AMP without precipitating antibody.

Authors:  I Weinryb; I M Michel; S M Hess
Journal:  Anal Biochem       Date:  1972-02       Impact factor: 3.365

6.  Stability of Met-enkephalin content in brain structures of morphine-dependent or foot shock-stressed rats.

Authors:  W Fratta; H Y Yang; J Hong; E Costa
Journal:  Nature       Date:  1977-08-04       Impact factor: 49.962

7.  Regional distribution of LEU and MET enkephalin in rat brain.

Authors:  H Y Yang; J S Hong; E Costa
Journal:  Neuropharmacology       Date:  1977-04       Impact factor: 5.250

8.  Endorphins in brains of decapitated and microwave-killed mice.

Authors:  A L Cheung; W B Stavinoha; A Goldstein
Journal:  Life Sci       Date:  1977-04-01       Impact factor: 5.037

9.  Some thoughts on the significance of enkephalin, the endogenous ligand.

Authors:  H W Kosterlitz; J Hughes
Journal:  Life Sci       Date:  1975-07-01       Impact factor: 5.037

10.  Identification of two related pentapeptides from the brain with potent opiate agonist activity.

Authors:  J Hughes; T W Smith; H W Kosterlitz; L A Fothergill; B A Morgan; H R Morris
Journal:  Nature       Date:  1975-12-18       Impact factor: 49.962
View more
  14 in total

1.  Pharmacodynamics and biophasic drug levels of methionine enkephalin.

Authors:  R J Erb; L M Her; A Abdallah; A K Mitra
Journal:  Pharm Res       Date:  1991-07       Impact factor: 4.200

2.  Release of met-enkephalin and its modulation through acetylcholine receptors in the rabbit superior colliculus.

Authors:  R B Illing; K E Nikolarakis; T Wichmann; W B Spatz; K Starke
Journal:  Exp Brain Res       Date:  1990       Impact factor: 1.972

3.  Decreases in endogenous opioid peptides in the rat medullo-coerulear pathway after chronic morphine treatment.

Authors:  E J Van Bockstaele; J Peoples; A S Menko; K McHugh; G Drolet
Journal:  J Neurosci       Date:  2000-12-01       Impact factor: 6.167

4.  Development of acute opioid tolerance and dependence in rat striatal neurones.

Authors:  J P Fry; W Zieglgänsberger; A Herz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-08       Impact factor: 3.000

5.  Immunocytochemical localization of enkephalin in the lateral septum of the guinea-pig brain. A light- and electron-microscopic study.

Authors:  J C Beauvillain; P Poulain; G Tramu
Journal:  Cell Tissue Res       Date:  1983       Impact factor: 5.249

Review 6.  Enkephalins and Endorphins. Clinical, pharmacological and therapeutic implications.

Authors:  D L Copolov; R D Helme
Journal:  Drugs       Date:  1983-12       Impact factor: 9.546

Review 7.  Neuroadaptive responses in brainstem noradrenergic nuclei following chronic morphine exposure.

Authors:  E J Van Bockstaele; A S Menko; G Drolet
Journal:  Mol Neurobiol       Date:  2001 Apr-Jun       Impact factor: 5.590

8.  Changes in the activity of nigral neurones induced by morphine and other opiates in rats with an intact brain and after prenigral decerebration.

Authors:  I Jurna
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-04       Impact factor: 3.000

9.  Chronic treatment with chlorpromazine, thioridazine or haloperidol increases striatal enkephalins and their release from rat brain.

Authors:  Z S Herman; M Huzarska; K Kmieciak-Kolada; J Kowalski
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

10.  Rapid changes in enkephalin levels in rat striatum and hypothalamus induced by diazepam.

Authors:  T Duka; M Wüster; A Herz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-10       Impact factor: 3.000
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.