Literature DB >> 7191479

Development of acute opioid tolerance and dependence in rat striatal neurones.

J P Fry, W Zieglgänsberger, A Herz.   

Abstract

Striatal neurones in the rat were frequently observed to develop tachyphylaxis to the specific, naloxone-antagonisable depressant effects of methionine- and leucine-enkephalin on spontaneous and L-glutamate-evoked activity. This loss of responsiveness to the enkephalins occurred within a few minutes of the repeated or prolonged application of these peptides and is suggested to reflect a form of acute tolerance. As with chronic opiate tolerance, the acute tolerance of single striatal neurones to the enkephalins appeared to be associated with dependence on these opioids, as evinced by the withdrawal-like hyperactivity that occurred upon terminating the application of the peptides or upon the microelectrophoresis of naloxone.

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Year:  1980        PMID： 7191479     DOI： 10.1007/bf00498571

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  27 in total

1.  Morphine tolerance and dependence: sensitivity of caudate nucleus neurons.

Authors:  N Dafny; M Brown; T F Burks; B M Rigor
Journal:  Brain Res       Date:  1979-02-23       Impact factor: 3.252

2.  Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance.

Authors:  S K Sharma; W A Klee; M Nirenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1975-08       Impact factor: 11.205

3.  Opioid peptide enkephalin: immunohistochemical mapping in rat central nervous system.

Authors:  R Simantov; M J Kuhar; G R Uhl; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1977-05       Impact factor: 11.205

4.  Neurophysiological changes in caudate nucleus and substantia nigra following morphine treatment.

Authors:  N Dafny; T F Burks
Journal:  Neuropharmacology       Date:  1976-09       Impact factor: 5.250

5.  Determination of methionine enkephalin in discrete regions of rat brain.

Authors:  J S Hong; H Y Yang; W Fratta; E Costa
Journal:  Brain Res       Date:  1977-10-07       Impact factor: 3.252

6.  Neuronal actions of endorphins and enkephalins among brain regions: a comparative microiontophoretic study.

Authors:  R A Nicoll; G R Siggins; N Ling; F E Bloom; R Guillemin
Journal:  Proc Natl Acad Sci U S A       Date:  1977-06       Impact factor: 11.205

7.  Actions of glutamic acid on spinal neurones.

Authors:  W Zieglgänsberger; E A Puil
Journal:  Exp Brain Res       Date:  1973-03-29       Impact factor: 1.972

8.  Localization with Pontamine Sky Blue of neurones in the brainstem responding to microiontophoretically applied compounds.

Authors:  R J Boakes; G J Bramwell; I Briggs; J M Candy; E Tempesta
Journal:  Neuropharmacology       Date:  1974-06       Impact factor: 5.250

9.  Another tungsten microelectrode.

Authors:  W R Levick
Journal:  Med Biol Eng       Date:  1972-07

10.  Enkephalin-induced depression of single neurons in brain areas with opiate receptors--antagonism by naloxone.

Authors:  R C Frederickson; F H Norris
Journal:  Science       Date:  1976-10-22       Impact factor: 47.728
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  3 in total

1.  Tolerance, opioid-induced allodynia and withdrawal associated allodynia in infant and young rats.

Authors:  M H Zissen; G Zhang; A McKelvy; J T Propst; J J Kendig; S M Sweitzer
Journal:  Neuroscience       Date:  2006-10-19       Impact factor: 3.590

2.  Gabapentin completely attenuated the acute morphine induced c-Fos expression in the rat striatum.

Authors:  Jamil Ahsan Kazi; Chen Fun Gee
Journal:  J Mol Neurosci       Date:  2007       Impact factor: 3.444

3.  Effects of excitatory amino acids and their antagonists on membrane and action potentials of cat caudate neurones.

Authors:  P L Herrling; R Morris; T E Salt
Journal:  J Physiol       Date:  1983-06       Impact factor: 5.182
  3 in total

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