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Literature DB >> 5547762

Action of fenfluramine on monoamine stores of rat tissues.

Abstract

1. Fenfluramine is an anorexogenic agent used clinically because it is devoid of central stimulatory effects.2. In rats, fenfluramine causes a depletion of 5-hydroxytryptamine (5-HT) from the telencephalon + diencephalon which lasts longer than one might have expected from the biological half life of fenfluramine. The depleting effects of fenfluramine do not extend to brainstem, stomach and heart stores of 5-HT.3. Fenfluramine causes an increase in the turnover rate of tel-diencephalic 5-HT but such an acceleration could not be detected in the 5-HT stores of the brainstem.4. It is inferred that the effects of fenfluramine on brain 5-hydroxytryptamine may be related to the accumulation of a fenfluramine metabolite in 5-HT neurones.5. High doses of fenfluramine cause a depletion of catecholamine stores in brain and heart but the time course of this depletion is shorter than the depletion of brain 5-HT.

Entities: Chemical Disease Species

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Year: 1971 PMID： 5547762 PMCID： PMC1702756 DOI： 10.1111/j.1476-5381.1971.tb09935.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

5 in total

1. [PSYCHOANALEPTIC ACTION OF SOME ANOREXIGENIC PHENYLETHYLAMINE DERIVATIVES].

Authors: J R BOISSIER; P SIMON; J FICHELLE; F HERVOUET
Journal: Therapie Date: 1965 Mar-Apr Impact factor: 2.070

2. [Comparative action of fenfluramine and amphetamine in rats with hypothalamic obesity].

Authors: A Bernier; N Sicot; J C Le Douarec
Journal: Rev Fr Etud Clin Biol Date: 1969-10

3. [Modification of the cerebral serotonin level in the rat by trifluoromethyl-2-phenyl ethyl aminopropane (Fenfluramine 768 S)].

Authors: J Duhault; C Verdavainne
Journal: Arch Int Pharmacodyn Ther Date: 1967-12

4. Studies on the site of action of a new anorectic agent, fenfluramine.

Authors: M H Foxwell; W H Funderburk; J W Ward
Journal: J Pharmacol Exp Ther Date: 1969-01 Impact factor: 4.030

5. Tissue concentrations of p-hydroxynorephedrine in rats injected with d-amphetamine: effect of pretreatment with desipramine.

Authors: A Groppetti; E Costa
Journal: Life Sci Date: 1969-06-01 Impact factor: 5.037

5 in total

31 in total

1. The effects of serotonergic and antiserotonergic drugs on the flexor reflex of spinal rat: a proposed model to evaluate the action on the central serotonin receptor.

Authors: J Maj; W Palider; L Baran
Journal: J Neural Transm Date: 1976 Impact factor: 3.575

2. Acute and chronic D-fenfluramine treatments have different effects on serotonin synthesis rates in the rat brain: an autoradiographic study.

Authors: F Yamane; Y Tohyama; M Diksic
Journal: Neurochem Res Date: 1999-12 Impact factor: 3.996

Action of fenfluramine on monoamine stores of rat tissues.

1. [PSYCHOANALEPTIC ACTION OF SOME ANOREXIGENIC PHENYLETHYLAMINE DERIVATIVES].

2. [Comparative action of fenfluramine and amphetamine in rats with hypothalamic obesity].

3. [Modification of the cerebral serotonin level in the rat by trifluoromethyl-2-phenyl ethyl aminopropane (Fenfluramine 768 S)].

4. Studies on the site of action of a new anorectic agent, fenfluramine.

5. Tissue concentrations of p-hydroxynorephedrine in rats injected with d-amphetamine: effect of pretreatment with desipramine.

1. The effects of serotonergic and antiserotonergic drugs on the flexor reflex of spinal rat: a proposed model to evaluate the action on the central serotonin receptor.

2. Acute and chronic D-fenfluramine treatments have different effects on serotonin synthesis rates in the rat brain: an autoradiographic study.

3. Effect of fenfluramine on 5-hydroxytryptamine uptake and release by rat blood platelets.

4. Adrenergic supersensitivity of the pupil in idiopathic headache.

5. The sympathomimetic activity of fenfluramine hydrochloride on rat vas deferens.

6. Peripheral effects of fenfluramine.

7. Fawn hooded rats are subsensitive to the food intake suppressant effects of 5-HT agonists.

8. Diminished amphetamine anorexia and enhanced fenfluramine anorexia after midbrain 6-hydroxydopamine.

9. Discriminative stimulus properties of fenfluramine: evidence for serotonergic involvement.

Review 10. Fenfluramine: a review of its pharmacological properties and therapeutic efficacy in obesity.