Literature DB >> 196897

Adrenergic supersensitivity of the pupil in idiopathic headache.

M Fanciullacci, P Galli, U Pietrini, F Sicuteri.   

Abstract

In idiopathic headache (IH) sufferers, phenylephrine and fenfluramine induce a pupillary dilatation respectively greater and lesser than in controls. The difference may be due to a supersensitivity of the iris alpha adrenoceptors caused by a deficiency of noradrenaline in the iris adrenergic nerve terminal of the IH sufferer. These findings seem to support the hypothesis of a brain receptorial, monoamine supersensitivity in IH.

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Year:  1977        PMID： 196897     DOI： 10.1007/bf01945983

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  6 in total

1.  [Binocular pupillometry for studies of clinical pharmacology].

Authors:  P Galli; M Fanciullacci; G Monetti; E Assenza
Journal:  Boll Soc Ital Biol Sper       Date:  1976-12-15

2.  [Fenfluramine and headche: pharmaco-clinical implications].

Authors:  E Bene; F Sicusteri; B Anselmi; P L Del Bianco
Journal:  Boll Soc Ital Biol Sper       Date:  1975-11-30

3.  Peripheral effects of fenfluramine.

Authors:  G E Mitchell; D R Mottram
Journal:  Br J Pharmacol       Date:  1976-06       Impact factor: 8.739

4.  5-hydroxytryptamine supersensitivity as a new theory of headache and central pain: a clinical pharmacological approach with p-chlorophenylalanine.

Authors:  F Sicuteri; B Anselmi; P L Del Bianco
Journal:  Psychopharmacologia       Date:  1973

5.  Fenfluramine headache.

Authors:  F Sircuteri; E Del Bene; B Anselmi
Journal:  Headache       Date:  1976-09       Impact factor: 5.887

6.  Action of fenfluramine on monoamine stores of rat tissues.

Authors:  E Costa; A Groppetti; A Revuelta
Journal:  Br J Pharmacol       Date:  1971-01       Impact factor: 8.739
  6 in total
  3 in total

1.  Post-endarterectomy headache and the role of the oculosympathetic system.

Authors:  M De Marinis; A Zaccaria; V Faraglia; P Fiorani; G Maira; A Agnoli
Journal:  J Neurol Neurosurg Psychiatry       Date:  1991-04       Impact factor: 10.154

2.  Morphine abstinence and serotonin supersensitivity in man: analogies with the mechanism of migraine?

Authors:  F Sicuteri; P L Del Bianco; B Anselmi
Journal:  Psychopharmacology (Berl)       Date:  1979-10       Impact factor: 4.530

Review 3.  Pupillary abnormalities due to sympathetic dysfunction in different forms of idiopathic headache.

Authors:  M De Marinis
Journal:  Clin Auton Res       Date:  1994-12       Impact factor: 4.435
  3 in total

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