Literature DB >> 2967518

Fawn hooded rats are subsensitive to the food intake suppressant effects of 5-HT agonists.

P Wang1, C S Aulakh, J L Hill, D L Murphy.   

Abstract

The food intake suppressant effects of three serotonin agonists, m-CPP (a selective 5-HT1B agonist), 8-OHDPAT (a selective 5-HT1A agonist) and fenfluramine (a 5-HT releasing agent) were compared in three different rat strains: Wistar, Sprague-Dawley (SD) and Fawn-Hooded (FH) rats. Administration of all three serotonin agonists produced dose-dependent decreases in 1 h food intake in all three strains. FH animals were significantly less sensitive to the food intake suppressant effects of all three serotonin agonists than either Wistar or SD rats. Body weight gain over the 9-week course of the study was also significantly less in FH animals than either Wistar or SD animals. These findings support some other data that Fawn Hooded rats, a strain with a peripheral platelet serotonin storage disorder, also possess altered central nervous system serotonergic function.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 2967518     DOI： 10.1007/bf00212855

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  30 in total

1.  Disposition and pharmacological effects of m-Chlorophenylpiperazine in rats.

Authors:  R W Fuller; H D Snoddy; N R Mason; J E Owen
Journal:  Neuropharmacology       Date:  1981-02       Impact factor: 5.250

2.  Human platelets possess high-affinity binding sites for 3H-imipramine.

Authors:  M S Briley; R Raisman; S Z Langer
Journal:  Eur J Pharmacol       Date:  1979-10-01       Impact factor: 4.432

3.  Brain monoamines and peptides: role in the control of eating behavior.

Authors:  S F Leibowitz
Journal:  Fed Proc       Date:  1986-04

4.  Absence of high-ffinity [3H]imipramine binding in platelets and cerebral cortex of fawn-hooded rats.

Authors:  A Dumbrille-Ross; S W Tang
Journal:  Eur J Pharmacol       Date:  1981-06-10       Impact factor: 4.432

5.  Brain tryptophan metabolism on the 5-hydroxytryptamine and kynurenine pathways in a strain of rats with a deficiency in platelet 5-HT.

Authors:  M H Joseph
Journal:  Br J Pharmacol       Date:  1978-07       Impact factor: 8.739

6.  Fenfluramine anorexia: a peripheral locus of action.

Authors:  R F Davies; J Rossi; J Panksepp; N J Bean; A J Zolovick
Journal:  Physiol Behav       Date:  1983-05

7.  Altered responses to serotonergic agents in Fawn-Hooded rats.

Authors:  G A Gudelsky; J I Koenig; H Y Meltzer
Journal:  Pharmacol Biochem Behav       Date:  1985-03       Impact factor: 3.533

8.  Chlorophenylpiperazine: a central serotonin agonist causing powerful anorexia in rats.

Authors:  R Samanin; T Mennini; A Ferraris; C Bendotti; F Borsini; S Garattini
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-08       Impact factor: 3.000

9.  Neurochemical and behavioural evidence for mediation of the hyperphagic action of 8-OH-DPAT by 5-HT cell body autoreceptors.

Authors:  P H Hutson; C T Dourish; G Curzon
Journal:  Eur J Pharmacol       Date:  1986-10-07       Impact factor: 4.432

10.  Action of fenfluramine on monoamine stores of rat tissues.

Authors:  E Costa; A Groppetti; A Revuelta
Journal:  Br J Pharmacol       Date:  1971-01       Impact factor: 8.739
View more
  9 in total

1.  Fawn-hooded rats show enhanced active behaviour in the forced swimming test, with no evidence for pituitary-adrenal axis hyperactivity.

Authors:  A Lahmame; F Gomez; A Armario
Journal:  Psychopharmacology (Berl)       Date:  1996-05       Impact factor: 4.530

2.  Daidzin and its antidipsotropic analogs inhibit serotonin and dopamine metabolism in isolated mitochondria.

Authors:  W M Keung; B L Vallee
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-03       Impact factor: 11.205

3.  Inhibitory neurotransmitter serotonin and excitatory neurotransmitter dopamine both decrease food intake in Chinese perch (Siniperca chuatsi).

Authors:  Yu-Hui He; Ling Li; Xu-Fang Liang; Shan He; Luo Zhao; Yan-Peng Zhang
Journal:  Fish Physiol Biochem       Date:  2017-09-19       Impact factor: 2.794

4.  Evidence that m-chlorophenylpiperazine-induced hyperthermia in rats is mediated by stimulation of 5-HT2C receptors.

Authors:  P Mazzola-Pomietto; C S Aulakh; K M Wozniak; D L Murphy
Journal:  Psychopharmacology (Berl)       Date:  1996-02       Impact factor: 4.530

5.  Rat strain differences in the vulnerability of serotonergic nerve endings to neurotoxic damage by p-chloroamphetamine.

Authors:  D Zhou; M Schreinert; J Pilz; G Huether
Journal:  J Neural Transm (Vienna)       Date:  1996       Impact factor: 3.575

6.  Local perfusion of mCPP into ventromedial hypothalamic nucleus, but not into lateral hypothalamic area and frontal cortex, inhibits food intake in rats.

Authors:  Katsuhito Hikiji; Koki Inoue; Shinichi Iwasaki; Kyuichiro Ichihara; Nobuo Kiriike
Journal:  Psychopharmacology (Berl)       Date:  2004-07       Impact factor: 4.530

7.  Evidence for involvement of 5-HT1C and 5-HT2 receptors in the food intake suppressant effects of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI).

Authors:  C S Aulakh; J L Hill; H T Yoney; D L Murphy
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

8.  Temperature, food intake, and locomotor activity effects of a 5-HT3 receptor agonist and two 5-HT3 receptor antagonists in rats.

Authors:  P Mazzola-Pomietto; C S Aulakh; D L Murphy
Journal:  Psychopharmacology (Berl)       Date:  1995-10       Impact factor: 4.530

9.  A process-based review of mouse models of pulmonary hypertension.

Authors:  Mita Das; Joshua Fessel; Haiyang Tang; James West
Journal:  Pulm Circ       Date:  2012-10       Impact factor: 3.017
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.