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Literature DB >> 5511571

Studies on the differentiation of thymus-derived lymphocytes.

Abstract

The development pathway from embryonic thymus-stem cell to peripheral thymus-derived lymphocyte has been demonstrated using the alloantigens theta (theta) and TL as surface markers of cell differentiation. On the basis of cytotoxicity tests carried out on CBA.H or A embryo thymus cultured in diffusion chambers and on CBA.H embryo thymus grafts and peripheral lymphocytes derived from them in AKR hosts, it has been concluded that two differentiation stages take place during the maturation of thymus-derived cells, namely a first step from stem cell to thymocyte and a second step from thymocyte to peripheral lymphocyte.

Entities: Disease

Mesh：

Substances：
Antigens

Year: 1970 PMID： 5511571 PMCID： PMC2180504 DOI： 10.1084/jem.132.6.1216

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

30 in total

10. Biological effects of Escherichia coli lipopolysaccharide (LPS) in vivo. II. Selection in the mouse thymus of PHA- and con A-responsive cells.

Authors: L Adorini; L Ruco; S Uccini; G S De Franceschi; C D Baroni; G Doria
Journal: Immunology Date: 1976-08 Impact factor: 7.397

Studies on the differentiation of thymus-derived lymphocytes.

1. Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse.

Review 2. Current concepts of the immunological function of the thymus.

3. Mouse thymic iso-antigens.

4. Autoradiographic analysis of lymphocyte proliferation in the thymus and in thymic lymphoma tissue.

5. Studies on human leucocytes in diffusion chambers on the chick chorioallantois.

6. Autoradiographic analysis of lymphopoiesis and lymphocyte migration in mice bearing multiple thymus grafts.

7. Serological analysis of thymus and spleen grafts.

8. Experimental studies on the development of the thymus.

9. Thymus cell migration.

10. Hemopoietic colony studies. V. Effect of hemopoietic organ stroma on differentiation of pluripotent stem cells.

1. Inhibition of T-cell differentiation by an antibody to a soluble thymic factor.

2. Morphological definition of thymocyte subpopulations.

3. Embryonic mouse thymocyte development. Enhancing effect of corticosterone at physiological levels.

4. Embryonic mouse thymus development: stem cell entry and differentiation.

5. Immunologic and genetic factors influencing reproduction. A review.

6. Studies on the differentiation of B lymphocytes in the mouse.

7. Surface glycoproteins of resting and activated human T lymphocytes.

8. The differentiation of murine thymocytes in vivo and in vitro.

9. Expression of the Thy-1 glycoprotein gene by DNA-mediated gene transfer.

10. Biological effects of Escherichia coli lipopolysaccharide (LPS) in vivo. II. Selection in the mouse thymus of PHA- and con A-responsive cells.