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Literature DB >> 783042

Biological effects of Escherichia coli lipopolysaccharide (LPS) in vivo. II. Selection in the mouse thymus of PHA- and con A-responsive cells.

L Adorini, L Ruco, S Uccini, G S De Franceschi, C D Baroni, G Doria.

Abstract

The effect of LPS injection on mouse thymocytes was examined by in vitro stimulation with PHA and Con A. Thymocytes from LPS treated mice were found more responsive than normal thymocytes to PHA and Con A. The increase of responsiveness was different for PHA and Con A, and dependent on the dose of LPS injected. This dose dependency suggests that LPS in vivo modifies the thymocyte population by progressively eliminating T1 cells and selecting T2 cells. These effects seem to be mediated by corticosteroids because they were prevented by adrenalectomy, a finding in agreement with the notion that the injection of cortisone induces similar cell changes in the thymus.

Entities: Chemical Gene Species

Mesh：

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Year: 1976 PMID： 783042 PMCID： PMC1445131

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

35 in total

1. THE IMMUNOLOGICAL ROLE OF DIFFERENT LYMPHOID ORGANS IN THE CHICKEN. II. THE IMMUNOLOGICAL COMPETENCE OF THYMIC CELL SUSPENSIONS.

Authors: N L WARNER
Journal: Aust J Exp Biol Med Sci Date: 1964-06

2. THE EFFECT OF ENDOTOXIN ON THE THYMUS OF YOUNG MICE.

Authors: D T ROWLANDS; H N CLAMAN; P D KIND
Journal: Am J Pathol Date: 1965-02 Impact factor: 4.307

3. Effect of hormones on lympatic tissue.

Authors: T F DOUGHERTY
Journal: Physiol Rev Date: 1952-10 Impact factor: 37.312

4. Potentiation of helper T cell function in IgE antibody responses by bacterial lipolysaccharide (LPS).

Authors: P E Newburger; T Hamaoka; D H Katz
Journal: J Immunol Date: 1974-09 Impact factor: 5.422

5. Cellular site of action of various adjuvants in antibody responses to hapten-carrier conjugates.

Authors: T Hamaoka; D H Katz
Journal: J Immunol Date: 1973-11 Impact factor: 5.422

6. Functional heterogeneity of murine lymphoid cells. 3. Differential responsiveness of T cells to phytohemagglutinin and concanavalin A as a probe for T cell subsets.

Authors: J D Stobo; W E Paul
Journal: J Immunol Date: 1973-02 Impact factor: 5.422

7. Evidence for subpopulation of mature lymphocytes within mouse thymus.

Authors: M Raff
Journal: Nat New Biol Date: 1971-02-10

8. Autoradiographic analysis of lymphocyte proliferation in the thymus and in thymic lymphoma tissue.

Authors: D Metcalf; M Wiadrowski
Journal: Cancer Res Date: 1966-03 Impact factor: 12.701

9. Activation of T and B lymphocytes in vitro. I. Regulatory influence of bacterial lipopolysaccharide (LPS) on specific T-cell helper function.

Authors: D Armerding; D H Katz
Journal: J Exp Med Date: 1974-01-01 Impact factor: 14.307

10. Termination of tolerance to human gamma globulin in mice by antigen and bacterial lipopolysaccharide (endotoxin).

Authors: J M Chiller; W O Weigle
Journal: J Exp Med Date: 1973-03-01 Impact factor: 14.307

5 in total

1. Biological effects of Escherichia coli lipopolysaccharide (LPS) in vivo. I. Selection in the mouse thymus of killer and helper cells.

Authors: C D Baroni; G S De Franceschi; S Uccini; L Adorini; G D Cnen; L Ruco
Journal: Immunology Date: 1976-08 Impact factor: 7.397