Literature DB >> 1093972

Inhibition of T-cell differentiation by an antibody to a soluble thymic factor.

E F Potworowski, D Lefebvre, G Lussier, J A Teodorczyk.   

Abstract

An antiserum to chicken soluble thymic factor (STF) was prepared in rabbits and absorbed with chicken thymocytes until it reacted only with thymic reticuloepithelial cells. When injected into 6-day-old embryonated eggs, this antiserum caused a severe depletion of small lymphocytes in the cortical region of the thymus which was filled with large undifferentiated cells. In addition, reticuloepithelial cells displayed a marked disruption of cytoplasmic elements. The percentage of thymic lymphocytes bearing the T antigen was greatly reduced. It is believed that a factor responsible for differentiation of stem cells into T cells has been inhibited.

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Year:  1975        PMID： 1093972      PMCID： PMC1445908     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  22 in total

1.  Induction of T-cell differentiation in the Bursa of Fabricius by a soluble thymus factor.

Authors:  J A Teodorczk; E F Potworowski
Journal:  Immunology       Date:  1975-04       Impact factor: 7.397

2.  T and B lymphocytes. Organ and age distribution in the chicken.

Authors:  E F Potworowski
Journal:  Immunology       Date:  1972-08       Impact factor: 7.397

3.  Differentiation of human bone marrow cells into T lymphocytes by in vitro incubation with thymic extracts.

Authors:  J L Touraine; G S Incefy; F Touraine; Y M Rho; R A Good
Journal:  Clin Exp Immunol       Date:  1974-05       Impact factor: 4.330

4.  Release of an immunologically active humoral factor from the isolated perfused thymus.

Authors:  O Ekwueme; A P Forrest
Journal:  Immunology       Date:  1974-01       Impact factor: 7.397

5.  Restoration of immunologic reactivity of thymectomized mice by calf thymus extracts.

Authors:  N Trainin; M Linker-Israeli
Journal:  Cancer Res       Date:  1967-02       Impact factor: 12.701

6.  Antigenic specificities of bursal and thymic lymphocytes in the chicken.

Authors:  A Forget; E F Potworowski; G Richer; A G Borduas
Journal:  Immunology       Date:  1970-09       Impact factor: 7.397

7.  Studies on antilymphocyte antibody in the chicken. I. Effect of rabbit antithymus and antibursa globulin on chicken embryos.

Authors:  B D Janković; K Isaković; S Petrović; D Vujić
Journal:  Clin Exp Immunol       Date:  1970-11       Impact factor: 4.330

8.  Studies on the differentiation of thymus-derived lymphocytes.

Authors:  J J Owen; M C Raff
Journal:  J Exp Med       Date:  1970-12-01       Impact factor: 14.307

9.  Preparation, assay, and partial purification of a thymic lymphocytopoietic factor (thymosin).

Authors:  A L Goldstein; F D Slater; A White
Journal:  Proc Natl Acad Sci U S A       Date:  1966-09       Impact factor: 11.205

10.  Increased reactivity of mouse spleen cells sensitized in vitro against syngeneic tumor cells in the presence of a thymic humoral factor.

Authors:  C Carnaud; D Ilfeld; I Brook; N Trainin
Journal:  J Exp Med       Date:  1973-12-01       Impact factor: 14.307
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  3 in total

1.  Thymus dependency of antigen-binding cells in the bone marrow and spleen of chicks.

Authors:  K Sato
Journal:  Immunology       Date:  1977-02       Impact factor: 7.397

2.  Effects of antithymic reticuloepithelial cells serum on the levels of circulating thymic factor and on the sensitivity to azathioprine of spleen spontaneous rosette-forming cells.

Authors:  E Garaci; V Del Gobbo; C Rinaldi-Garaci
Journal:  Experientia       Date:  1976-11-15

3.  Parvalbumin and calretinin in the avian thymus.

Authors:  E Király; M R Celio
Journal:  Anat Embryol (Berl)       Date:  1993-10
  3 in total

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