Literature DB >> 5496138

Stereospecificity of anesthetic activity, distribution, inactivation and protein binding of the optical antipodes of two N-methylated barbiturates.

H Büch, J Knabe, W Buzello, W Rummel.   

Abstract

Entities:  

Mesh：

Substances：

Year:  1970        PMID： 5496138

Source DB:  PubMed          Journal:  J Pharmacol Exp Ther        ISSN： 0022-3565            Impact factor:   4.030


× No keyword cloud information.
  9 in total

Review 1.  Methods of determining plasma and tissue binding of drugs. Pharmacokinetic consequences.

Authors:  G M Pacifici; A Viani
Journal:  Clin Pharmacokinet       Date:  1992-12       Impact factor: 6.447

Review 2.  Electroencephalogram effect measures and relationships between pharmacokinetics and pharmacodynamics of centrally acting drugs.

Authors:  J W Mandema; M Danhof
Journal:  Clin Pharmacokinet       Date:  1992-09       Impact factor: 6.447

Review 3.  Stereoselectivity in clinical pharmacokinetics and drug development.

Authors:  D B Campbell
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1990 Apr-Jun       Impact factor: 2.441

4.  Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic.

Authors:  Pavel Y Savechenkov; Xi Zhang; David C Chiara; Deirdre S Stewart; Rile Ge; Xiaojuan Zhou; Douglas E Raines; Jonathan B Cohen; Stuart A Forman; Keith W Miller; Karol S Bruzik
Journal:  J Med Chem       Date:  2012-07-17       Impact factor: 7.446

5.  Affinities of barbiturates for the GABA-receptor complex and A1 adenosine receptors: a possible explanation of their excitatory effects.

Authors:  M J Lohse; S Böser; K N Klotz; U Schwabe
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-08       Impact factor: 3.000

6.  Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of heptabarbital using aperiodic EEG analysis.

Authors:  J W Mandema; M Danhof
Journal:  J Pharmacokinet Biopharm       Date:  1990-10

7.  Stereochemical dependence of pharmacological activity in a series of optically active N-methylated barbiturates.

Authors:  H P Büch; F Schneider-Affeld; W Rummel
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1973       Impact factor: 3.000

8.  Species of cytochrome P-450 in rat liver microsomes with different stereoselectivity for the binding and monooxygenation of (+)- and (-)-methylphenobarbital.

Authors:  W Bohn; V Ullrich; H Staudinger
Journal:  Naunyn Schmiedebergs Arch Pharmakol       Date:  1971

9.  Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1 β3 γ2L GABAA receptor account for their in vivo effects.

Authors:  Rooma Desai; Pavel Y Savechenkov; Dorota Zolkowska; Ri Le Ge; Michael A Rogawski; Karol S Bruzik; Stuart A Forman; Douglas E Raines; Keith W Miller
Journal:  J Physiol       Date:  2015-11-15       Impact factor: 5.182
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.