Literature DB >> 4267317

Stereochemical dependence of pharmacological activity in a series of optically active N-methylated barbiturates.

H P Büch, F Schneider-Affeld, W Rummel.   

Abstract

Entities:  

Mesh：

Substances：

Year:  1973        PMID： 4267317     DOI： 10.1007/bf00501159

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


× No keyword cloud information.
  14 in total

1.  Pharmacology of stereoisomers of 1-methyl-5-(1-methyl-2-pentynyl)-5-allyl-barbituric acid.

Authors:  W R GIBSON; W J DORAN; W C WOOD; E E SWANSON
Journal:  J Pharmacol Exp Ther       Date:  1959-01       Impact factor: 4.030

2.  Optical isomerism and pharmacological action, a generalization.

Authors:  C C PFEIFFER
Journal:  Science       Date:  1956-07-06       Impact factor: 47.728

3.  Metabolism and cytochrome P-450 binding spectra of (+)- and (-)-hexobarbital in rat liver microsomes.

Authors:  E Degkwitz; V Ullrich; H Staudinger
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1969-05

4.  [Synthesis and configuration of optically active N-methylbarbiturates. 16. Derivatives of barbituric acid].

Authors:  J Knabe; H Junginger
Journal:  Pharmazie       Date:  1972-07       Impact factor: 1.267

5.  [Absolute configuration of some C-5 disubstituted 1-methylbarbituric acids and of their degradation products].

Authors:  J Knabe; H Junginger; W Geismar
Journal:  Justus Liebigs Ann Chem       Date:  1970

6.  A study of the excitatory effects of barbiturates.

Authors:  H Downes; R S Perry; R E Ostlund; R Karler
Journal:  J Pharmacol Exp Ther       Date:  1970-12       Impact factor: 4.030

7.  Stereospecificity of anesthetic activity, distribution, inactivation and protein binding of the optical antipodes of two N-methylated barbiturates.

Authors:  H Büch; J Knabe; W Buzello; W Rummel
Journal:  J Pharmacol Exp Ther       Date:  1970-12       Impact factor: 4.030

8.  [Narcotic effectiveness and tissue distribution of the optical antipodes of the pentobarbitals in the rat].

Authors:  H Büch; W Grund; W Buzello; W Rummel
Journal:  Biochem Pharmacol       Date:  1969-05       Impact factor: 5.858

9.  [Comparison of distribution, narcotic activity and metabolic elimination of the optical antipodes of methylphenobarbital].

Authors:  H Büch; W Buzello; O Neurohr; W Rummel
Journal:  Biochem Pharmacol       Date:  1968-12       Impact factor: 5.858

10.  Differences in anaesthetic properties between the optical antipodes of hexobarbital in the rat.

Authors:  G Wahlström
Journal:  Life Sci       Date:  1966-10       Impact factor: 5.037
View more
  9 in total

1.  Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic.

Authors:  Pavel Y Savechenkov; Xi Zhang; David C Chiara; Deirdre S Stewart; Rile Ge; Xiaojuan Zhou; Douglas E Raines; Jonathan B Cohen; Stuart A Forman; Keith W Miller; Karol S Bruzik
Journal:  J Med Chem       Date:  2012-07-17       Impact factor: 7.446

2.  Affinities of barbiturates for the GABA-receptor complex and A1 adenosine receptors: a possible explanation of their excitatory effects.

Authors:  M J Lohse; S Böser; K N Klotz; U Schwabe
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-08       Impact factor: 3.000

3.  The site of action of the optical isomers of 1-methyl-5-phenyl-5-propyl barbituric acid.

Authors:  W Grossmann; I Jurna; C Theres
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1974       Impact factor: 3.000

Review 4.  Molecular biology of inhibitory amino acid receptors.

Authors:  R S Duman; P M Sweetnam; P A Gallombardo; J F Tallman
Journal:  Mol Neurobiol       Date:  1987 Spring-Summer       Impact factor: 5.590

5.  Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology.

Authors:  E J Ariëns
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953

6.  The discriminative stimulus properties of barbiturate stereoisomers.

Authors:  W D Wessinger; G R Wenger
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

Review 7.  Pharmacological importance of stereochemical resolution of enantiomeric drugs.

Authors:  M R Islam; J G Mahdi; I D Bowen
Journal:  Drug Saf       Date:  1997-09       Impact factor: 5.228

8.  Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β- Interface.

Authors:  Selwyn S Jayakar; Xiaojuan Zhou; Pavel Y Savechenkov; David C Chiara; Rooma Desai; Karol S Bruzik; Keith W Miller; Jonathan B Cohen
Journal:  J Biol Chem       Date:  2015-07-30       Impact factor: 5.157

9.  Pharmacodynamic modeling of the EEG effects of ketamine and its enantiomers in man.

Authors:  J Schüttler; D R Stanski; P F White; A J Trevor; Y Horai; D Verotta; L B Sheiner
Journal:  J Pharmacokinet Biopharm       Date:  1987-06
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.