Literature DB >> 5427356

Amantadine-dopamine interaction: possible mode of action in Parkinsonism.

R P Grelak, R Clark, J M Stump, V G Vernier.   

Abstract

Intravenous doses of amantadine hydrochloride, an antiviral drug, as small as 0.08 milligram per kilogram may release dopamine and other catecholamines from neuronal storage sites in dogs primed with dopamine. This release may account for the reported efficacy of amantadine hydrochloride in the treatment of human parkinsonism.

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Year:  1970        PMID： 5427356     DOI： 10.1126/science.169.3941.203

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  30 in total

1.  On the synchronizing effect of amantadine-1-hydrochlorid (Symmetrel) on pathological EEG-activity.

Authors:  J Vardi; M Streifler
Journal:  J Neural Transm       Date:  1975       Impact factor: 3.575

Review 2.  Microbe hunting.

Authors:  W Ian Lipkin
Journal:  Microbiol Mol Biol Rev       Date:  2010-09       Impact factor: 11.056

Review 3.  The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives.

Authors:  Lukas Wanka; Khalid Iqbal; Peter R Schreiner
Journal:  Chem Rev       Date:  2013-02-25       Impact factor: 60.622

4.  Long-term therapy of Parkinson's disease with amantadine, alone and combined with levodopa.

Authors:  L R Zeldowicz; J Hubermann
Journal:  Can Med Assoc J       Date:  1973-10-06       Impact factor: 8.262

Review 5.  Levodopa: a review of its pharmacological properties and therapeutic use with particular reference to Parkinsonism.

Authors:  R N Brogden; T M Speight; G S Avery
Journal:  Drugs       Date:  1971       Impact factor: 9.546

6.  On the effect of amantadine on ATP content and ATPase activity in brain and blood of rats.

Authors:  V A Velkov
Journal:  Experientia       Date:  1974-04-15

7.  [Differential treatment of Parkinson's disease, with special reference to the possibility of iatrogenic disorders (author's transl)].

Authors:  W Gehlen
Journal:  Arch Psychiatr Nervenkr (1970)       Date:  1974-04-09

8.  Failure of amantadine to modify serum growth hormone and insulin levels.

Authors:  F Cavagnini; A E Pontiroli; U Raggi; M Peracchi; A Malinverni
Journal:  Experientia       Date:  1973-05-15

9.  The effect of intracerebroventricular administration of catecholamines and their antagonists on rectal temperature of Mastomys natalensis.

Authors:  R Shukla; R C Srimal; B N Dhawan
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-12       Impact factor: 3.000

10.  Amantadine-HCl (Symmetrel) in the management of Parkinson's disease: a double-blind cross-over study.

Authors:  A Barbeau; H Mars; M I Botez; M Joubert
Journal:  Can Med Assoc J       Date:  1971-07-10       Impact factor: 8.262
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