Literature DB >> 5419851

Hundred day leukemia: preferential induction in rat by pulse-doses of 7,8,12-trimethylbenz(a)anthracene.

C Huggins, L Grand, H Oka.   

Abstract

A series of pulse-doses of 7, 8, 12-trimethylbenz(a)anthracene-induced leukemia rapidly and consistently in very high yield in rats of Long-Evans (L-E) strain. The predominant type was a diffuse hepatic leukemia of erythroblastic stem cells. Progressive hypothermia and a decline in pituitary function are newly recognized signs of advanced leukemia in rat.

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Year:  1970        PMID： 5419851      PMCID： PMC2138796          DOI： 10.1084/jem.131.2.321

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  6 in total

1.  Induction of leukemia and ovarian tumors in mice by pulse-doses of polycyclic aromatic hydrocarbons.

Authors:  K Uematsu; C Huggins
Journal:  Mol Pharmacol       Date:  1968-09       Impact factor: 4.436

2.  Composition and preparation of experimental intravenous fat emulsions.

Authors:  P E Schurr
Journal:  Cancer Res       Date:  1969-01       Impact factor: 12.701

3.  Selective destruction of adrenal cortex by pulse doses of derivatives of 12-methylbenz(a)anthracene.

Authors:  C Huggins; S Morii; J Pataki
Journal:  Proc Natl Acad Sci U S A       Date:  1969-03       Impact factor: 11.205

4.  Induction of leukemia in rat by pulse doses of 7,12-dimethylbenz(a)anthracene.

Authors:  C B Huggins; T Sugiyama
Journal:  Proc Natl Acad Sci U S A       Date:  1966-01       Impact factor: 11.205

5.  SELECTIVE DESTRUCTION IN TESTIS INDUCED BY 7,12-DIMETHYLBENZ [a] ANTHRACENE.

Authors:  E Ford; C Huggins
Journal:  J Exp Med       Date:  1963-07-01       Impact factor: 14.307

6.  Selective adrenal necrosis and apoplexy induced by 7, 12-dimethylbenz(a)anthracene.

Authors:  C HUGGINS; S MORII
Journal:  J Exp Med       Date:  1961-11-01       Impact factor: 14.307
  6 in total
  14 in total

1.  Recovery patterns of rat hemopoietic stem cells between pulse doses of 7,12-dimethylbenz(a)anthracene (DMBA) applied in a leukemogenic regimen.

Authors:  I Fohlmeister; O Hohentanner; A Porr
Journal:  J Cancer Res Clin Oncol       Date:  1986       Impact factor: 4.553

2.  Incomplete chromatin condensation in enlarged rat myelocytic leukemia cells.

Authors:  Gyorgy Trencsenyi; Gabor Nagy; Fruzsina Bako; Pal Kertai; Gaspar Banfalvi
Journal:  DNA Cell Biol       Date:  2011-09-23       Impact factor: 3.311

3.  [Leukemia L 5222 of the rat strain BD IX. An ethylnitrosourea-induced monocytic-myeloic transplantable form for cytochemical and chemotherapeutic studies].

Authors:  S Ivankovic; W J Zeller
Journal:  Blut       Date:  1974-04

4.  Azo dyes prevent hydrocarbon-induced leukemia in the rat.

Authors:  C B Huggins; N Ueda; A Russo
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

5.  Dimethylsulfoxide-induced differentiation and hemoglobin synthesis in tissue cultures of rat erythroleukemia cells transformed by 7,12-dimethylbenz(a)anthracene.

Authors:  N Kluge; W Ostertag; T Sugiyama; D Arndt-Jovin; G Steinheider; M Furusawa; S K Dube
Journal:  Proc Natl Acad Sci U S A       Date:  1976-04       Impact factor: 11.205

6.  Specific induction of erythroleukemia and myelogenous leukemia in Sprague-Dawley rats.

Authors:  C B Huggins; L Grand; N Ueda
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

7.  On the pathogenesis of preleukemic myelodysplastic syndromes: development of a dysplastic hemopoietic proliferation in the rat after a single pulse dose of dimethylbenz(a)anthracene (DMBA).

Authors:  I Fohlmeister; H E Schaefer; R Fischer
Journal:  J Cancer Res Clin Oncol       Date:  1982       Impact factor: 4.553

8.  Changes in chromosomes of bone marrow after intravenous injections of 7,12-dimethylbenz(a)anthracene and related compounds.

Authors:  E D Rees; S K Majumdar; A Shuck
Journal:  Proc Natl Acad Sci U S A       Date:  1970-08       Impact factor: 11.205

9.  N-Nitroso-N-methylurea elicits mammary cancer in resistant and sensitive rat strains.

Authors:  C B Huggins; N Ueda; M Wiessler
Journal:  Proc Natl Acad Sci U S A       Date:  1981-02       Impact factor: 11.205

Review 10.  Myelodysplastic syndromes: pathogenesis, functional abnormalities, and clinical implications.

Authors:  A Jacobs
Journal:  J Clin Pathol       Date:  1985-11       Impact factor: 3.411
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