Literature DB >> 6785750

N-Nitroso-N-methylurea elicits mammary cancer in resistant and sensitive rat strains.

C B Huggins, N Ueda, M Wiessler.   

Abstract

A single intravenous (i.v.) injection of the water-soluble mammary carcinogen N-nitroso-N-methylurea (NMU; 35 mg/kg of body weight) elicited cancer of the breast in young female rats of two strains in the following incidence: Long-Evans strain, 4%; Sprague-Dawley strain, 70%. In sisters of these rats, a set of 5 i.v. injections of NMU (35 mg/kg at biweekly intervals) evoked mammary carcinoma as follows: Long-Evans strain, 76%; Sprague-Dawley strain, 100%. In its effectiveness in evoking mammary cancer in Sprague-Dawley rats, the lipid-soluble mammary carcinogen 7,8,12-trimethylbenz[a]anthracene exceeded NMU in rapidity of development of cancer and in tumor yield.

Entities:  

Mesh：

Substances：

Year:  1981        PMID： 6785750      PMCID： PMC319972          DOI： 10.1073/pnas.78.2.1185

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  9 in total

1.  [INDUCTION OF CANCER BY A SINGLE DOSE OF METHYLNITROSO-UREA AND VARIOUS DIALKYLNITROSAMINES IN RATS].

Authors:  H DRUCKREY; D STEINHOFF; R PREUSSMANN; S IVANKOVIC
Journal:  Z Krebsforsch       Date:  1964-02-07

2.  Race-strain factor related to hydrocarbon-induced mammary cancer in rats.

Authors:  K L SYDNOR; O BUTENANDT; F P BRILLANTES; C HUGGINS
Journal:  J Natl Cancer Inst       Date:  1962-10       Impact factor: 13.506

3.  Mammary cancer induced by a single feeding of polymucular hydrocarbons, and its suppression.

Authors:  C HUGGINS; L C GRAND; F P BRILLANTES
Journal:  Nature       Date:  1961-01-21       Impact factor: 49.962

4.  [Organotropic carcinogenic effects of 65 various N-nitroso- compounds on BD rats].

Authors:  H Druckrey; R Preussmann; S Ivankovic; D Schmähl
Journal:  Z Krebsforsch       Date:  1967

5.  Composition and preparation of experimental intravenous fat emulsions.

Authors:  P E Schurr
Journal:  Cancer Res       Date:  1969-01       Impact factor: 12.701

6.  Induction of leukemia in rat by pulse doses of 7,12-dimethylbenz(a)anthracene.

Authors:  C B Huggins; T Sugiyama
Journal:  Proc Natl Acad Sci U S A       Date:  1966-01       Impact factor: 11.205

7.  Azo dyes prevent hydrocarbon-induced leukemia in the rat.

Authors:  C B Huggins; N Ueda; A Russo
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

8.  N-nitrosomethylurea as mammary gland carcinogen in rats.

Authors:  P M Gullino; H M Pettigrew; F H Grantham
Journal:  J Natl Cancer Inst       Date:  1975-02       Impact factor: 13.506

9.  Hundred day leukemia: preferential induction in rat by pulse-doses of 7,8,12-trimethylbenz(a)anthracene.

Authors:  C Huggins; L Grand; H Oka
Journal:  J Exp Med       Date:  1970-02       Impact factor: 14.307
  9 in total
  12 in total

1.  Use of Biomarker Modulation in Normal Mammary Epithelium as a Correlate for Efficacy of Chemopreventive Agents Against Chemically Induced Cancers.

Authors:  Ronald A Lubet; Brandy M Heckman-Stoddard; Jennifer T Fox; Fariba Moeinpour; M Margaret Juliana; Robert H Shoemaker; Clinton J Grubbs
Journal:  Cancer Prev Res (Phila)       Date:  2019-12-23

2.  Genetic identification of distinct loci controlling mammary tumor multiplicity, latency, and aggressiveness in the rat.

Authors:  Xiaojiang Quan; Jean-François Laes; Daniel Stieber; Michèle Rivière; Jose Russo; Dirk Wedekind; Wouter Coppieters; Frédéric Farnir; Michel Georges; Josiane Szpirer; Claude Szpirer
Journal:  Mamm Genome       Date:  2006-04-04       Impact factor: 2.957

Review 3.  Induced mammary cancer in rat models: pathogenesis, genetics, and relevance to female breast cancer.

Authors:  James L Miller; Arianna P Bartlett; Rebecca M Harman; Prabin Dhangada Majhi; D Joseph Jerry; Gerlinde R Van de Walle
Journal:  J Mammary Gland Biol Neoplasia       Date:  2022-07-29       Impact factor: 2.698

4.  Dielectrophoretic field-flow fractionation system for detection of aquatic toxicants.

Authors:  Sittisak Pui-ock; Mathuros Ruchirawat; Peter Gascoyne
Journal:  Anal Chem       Date:  2008-09-13       Impact factor: 6.986

5.  Regression of myelocytic leukemia in rats after hypophysectomy.

Authors:  C B Huggins; N Ueda
Journal:  Proc Natl Acad Sci U S A       Date:  1984-01       Impact factor: 11.205

6.  Effect of molybdenum supplementation on N-nitroso-N-methylurea-induced mammary carcinogenesis and molybdenum excretion in rats.

Authors:  C D Seaborn; S P Yang
Journal:  Biol Trace Elem Res       Date:  1993 Nov-Dec       Impact factor: 3.738

7.  Specific induction of erythroleukemia and myelogenous leukemia in Sprague-Dawley rats.

Authors:  C B Huggins; L Grand; N Ueda
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

8.  Concordant effects of aromatase inhibitors on gene expression in ER+ Rat and human mammary cancers and modulation of the proteins coded by these genes.

Authors:  Yan Lu; Ming You; Zara Ghazoui; Pengyuan Liu; Peter T Vedell; Weidong Wen; Ann M Bode; Clinton J Grubbs; Ronald A Lubet
Journal:  Cancer Prev Res (Phila)       Date:  2013-09-25

9.  Effect of age on dose-response relationship in carcinogenesis induced by single administration of N-nitrosomethylurea in female rats.

Authors:  V N Anisimov
Journal:  J Cancer Res Clin Oncol       Date:  1988       Impact factor: 4.553

Review 10.  Mapping Mammary Tumor Traits in the Rat.

Authors:  Michael J Flister; Amit Joshi; Carmen Bergom; Hallgeir Rui
Journal:  Methods Mol Biol       Date:  2019
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.