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Literature DB >> 5347182

Virulence of temperature-sensitive mutants of influenza virus.

Abstract

The acquisition of temperature-mutant (ts) defects in a strain of influenza virus has been shown in mice to be associated with diminished virulence, though the antibody-producing stimulus remained. It is suggested that three advantages may make ts strains potential sources of attenuated live influenza vaccine-the ease of obtaining the strains, the ease of testing the vaccine strain, and the high yield of vaccine doses from a single egg.

Entities: Species

Mesh：

Substances：
Influenza Vaccines

Year: 1969 PMID： 5347182 PMCID： PMC1984656 DOI： 10.1136/bmj.3.5673.757

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

3 in total

1. [Attenuation of the virus of encephalomyocarditis of the mouse by culture at low temperature. Influence of hypo- and hyperthermia on the course of the experimental disease].

Authors: Y PEROL-VAUCHEZ; P TOURNIER; M LWOFF
Journal: C R Hebd Seances Acad Sci Date: 1961-11-06

2. Protective effects of specific immunity to viral neuraminidase on influenza virus infection of mice.

Authors: J L Schulman; M Khakpour; E D Kilbourne
Journal: J Virol Date: 1968-08 Impact factor: 5.103

3. Disquisitions of Original Antigenic Sin. I. Evidence in man.

Authors: R G Webster
Journal: J Exp Med Date: 1966-09-01 Impact factor: 14.307

3 in total

14 in total

1. Virulence of temperature-sensitive mutants of foot-and-mouth disease virus.

Authors: J S MacKenzie
Journal: Arch Virol Date: 1975 Impact factor: 2.574

2. Biochemistry and pathogenicity of echovirus 9. III. Thermosensitive mutants of echovirus 9, strain Barty, with reduced pathogenicity for newborn mice.

Authors: B Rosenwirth; D Ziegenhagen; H J Eggers
Journal: Med Microbiol Immunol Date: 1988 Impact factor: 3.402

6. Linkage between reproductive capacity at increased temperature and neurotropic activity in A-NWS HONi (HON1) influenza virus.

Authors: J Svobodová; E Tucková; V Vonka
Journal: Infect Immun Date: 1974-08 Impact factor: 3.441

7. Growth and pathogenicity of influenza viruses in organ cultures of ciliated epithelium. I. Experiments in ferret and human tissue.

Authors: K Hara; A S Beare; D A Tyrrell
Journal: Arch Gesamte Virusforsch Date: 1974

Virulence of temperature-sensitive mutants of influenza virus.

1. [Attenuation of the virus of encephalomyocarditis of the mouse by culture at low temperature. Influence of hypo- and hyperthermia on the course of the experimental disease].

2. Protective effects of specific immunity to viral neuraminidase on influenza virus infection of mice.

3. Disquisitions of Original Antigenic Sin. I. Evidence in man.

1. Virulence of temperature-sensitive mutants of foot-and-mouth disease virus.

2. Biochemistry and pathogenicity of echovirus 9. III. Thermosensitive mutants of echovirus 9, strain Barty, with reduced pathogenicity for newborn mice.

3. A spontaneous temperature sensitive mutant of Japanese encephalitis virus: preliminary characterization.

4. In vivo behaviour of a temperature-sensitive (ts) mutant of herpesvirus hominis type 2.

5. Inoculation of hamsters with a temperature sensitive (ts) mutant of parainfluenza 3 virus.

6. Linkage between reproductive capacity at increased temperature and neurotropic activity in A-NWS HONi (HON1) influenza virus.

7. Growth and pathogenicity of influenza viruses in organ cultures of ciliated epithelium. I. Experiments in ferret and human tissue.

8. Virulence of a temperature-sensitive mutant of western equine encephalitis virus.

9. A comparative study of attenuated influenza viruses.

10. Evidence for a mouse pathogenicity locus in certain temperature-sensitive mutants of foot-and-mouth disease virus.