Literature DB >> 5316742

A comparative study of attenuated influenza viruses.

A S Beare, H F Maassab, D A Tyrrell, A N Slepuskin, T S Hall.   

Abstract

Influenza A and influenza B viruses were adapted to growth at 25 degrees C. When given to volunteer subjects, the viruses were attenuated but remained infective and antigenic. The minimum immunizing dose of an egg-adapted virus appeared to be 10(5.0) EID(50). Cloning by plaque selection at 25 degrees C gave seed cultures of relatively low infectivity titres. These titres were increased when necessary by passage at 33 degrees C. No reversion to virulence was observed.Viruses attenuated in the United Kingdom and the USA were compared in volunteer trials with vaccine strains that had already been used in the USSR for mass immunization. Results were broadly similar. Currently available methods of attenuation and work with temperature-sensitive mutants are reviewed.

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Year:  1971        PMID： 5316742      PMCID： PMC2427844     

Source DB:  PubMed          Journal:  Bull World Health Organ        ISSN： 0042-9686            Impact factor:   9.408


  11 in total

1.  Adaptation and growth characteristics of influenza virus at 25 degrees c.

Authors:  H F Maassab
Journal:  Nature       Date:  1967-02-11       Impact factor: 49.962

2.  Mutants of influenza virus.

Authors:  J Mills; R M Chanock; D W Alling
Journal:  Br Med J       Date:  1969-12-13

3.  Plaque formation of influenza virus at 25 degrees C.

Authors:  H F Maassab
Journal:  Nature       Date:  1968-08-10       Impact factor: 49.962

4.  Isolation of temperature-sensitive mutants and the construction of a preliminary genetic map for influenza virus.

Authors:  J S Mackenzie
Journal:  J Gen Virol       Date:  1970-01       Impact factor: 3.891

5.  Biologic and immunologic characteristics of cold-adapted influenza virus.

Authors:  H F Maassab
Journal:  J Immunol       Date:  1969-03       Impact factor: 5.422

6.  Investigetion into the attenuation of influenza viruses by serial passage.

Authors:  A S Beare; M L Bynoe; D A Tyrrell
Journal:  Br Med J       Date:  1968-11-23

7.  Virulence of temperature-sensitive mutants of influenza virus.

Authors:  J S Mackenzie
Journal:  Br Med J       Date:  1969-09-27

8.  Attenuation of human influenza A viruses.

Authors:  A S Beare; M L Bynoe
Journal:  Br Med J       Date:  1969-10-25

9.  The efficacy of live influenza vaccines.

Authors:  A A Smorodincev
Journal:  Bull World Health Organ       Date:  1969       Impact factor: 9.408

10.  Laboratory characteristics of attenuated influenza viruses.

Authors:  A S Beare
Journal:  Bull World Health Organ       Date:  1969       Impact factor: 9.408
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  10 in total

1.  A clinical trial of WRL 105 strain live attenuated influenza vaccine comparing four methods of intranasal vaccination.

Authors:  D S Freestone; C H Bowker; E Letley; R D Ferris; W G White; G M Barnes
Journal:  J Hyg (Lond)       Date:  1976-06

2.  The production of live attenuated influenza A strains by recombination with A/Okuda/57 (H2N2).

Authors:  D McCahon; A S Beare; V Stealey
Journal:  Postgrad Med J       Date:  1976-06       Impact factor: 2.401

3.  Clinical trial with "R-75" strain live, attenuated, serum inhibitor-resistant intranasal influenza B vaccine.

Authors:  M J Spencer; J D Cherry; K R Powell
Journal:  J Clin Microbiol       Date:  1977-06       Impact factor: 5.948

4.  The role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza A2 and B viruses.

Authors:  D Hobson; R L Curry; A S Beare; A Ward-Gardner
Journal:  J Hyg (Lond)       Date:  1972-12

5.  Growth and pathogenicity of influenza viruses in organ cultures of ciliated epithelium. I. Experiments in ferret and human tissue.

Authors:  K Hara; A S Beare; D A Tyrrell
Journal:  Arch Gesamte Virusforsch       Date:  1974

6.  Neuraminidase and resistance to vaccination with live influenza A2 Hong Kong vaccines.

Authors:  A N Slepushkin; G C Schild; A S Beare; S Chinn; D A Tyrrell
Journal:  J Hyg (Lond)       Date:  1971-12

7.  Cold adapted variants of influenza A. II. Comparison of the genetic and biological properties of ts mutants and recombinants of the cold adapted A/AA/6/60 strain.

Authors:  S B Spring; H F Maassab; A P Kendal; B R Murphy; R M Chanock
Journal:  Arch Virol       Date:  1977       Impact factor: 2.574

8.  Cold-adapted variants of influenza A virus: evaluation in adult seronegative volunteers of A/Scotland/840/74 and A/Victoria/3/75 cold-adapted recombinants derived from the cold-adapted A/Ann Arbor/6/60 strain.

Authors:  B R Murphy; H P Holley; E J Berquist; M M Levine; S B Spring; H F Maassab; A P Kendal; R M Chanock
Journal:  Infect Immun       Date:  1979-02       Impact factor: 3.441

9.  Humoral and cellular immune responses of seronegative children vaccinated with a cold-adapted influenza A/HK/123/77 (H1N1) recombinant virus.

Authors:  A Lazar; N Okabe; P F Wright
Journal:  Infect Immun       Date:  1980-03       Impact factor: 3.441

10.  Growth of some attenuated influenza viruses in hamster tracheal organ cultures.

Authors:  P Reeve; B Gerendas; H Walzl
Journal:  Med Microbiol Immunol       Date:  1978-11-17       Impact factor: 3.402
  10 in total

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