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Literature DB >> 4338168

Inoculation of hamsters with a temperature sensitive (ts) mutant of parainfluenza 3 virus.

Abstract

The multiplication pattern of a temperature-sensitive (ts) mutant of bovine parainfluenza 3 virus was studied in hamsters and compared with that of a virulent virus strain. The ts mutant was recovered regularly from the nasal mucosa and not from the lungs, whereas the virulent virus multiplied in the lungs as well as in the nasal mucosa.The serological response induced by the mutant was comparable to that obtained after inoculation of the virulent virus.This ts mutant may be a potential candidate for a live intranasal vaccine against bovine parainfluenza 3 infection.

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Viral Vaccines

Year: 1972 PMID： 4338168 PMCID： PMC2130049 DOI： 10.1017/s0022172400022282

Source DB: PubMed Journal: J Hyg (Lond) ISSN： 0022-1724

6 in total

7 in total

Inoculation of hamsters with a temperature sensitive (ts) mutant of parainfluenza 3 virus.

1. Parainfluenza-3 vaccine in cattle: comparative efficacy of intranasal and intramuscular routes.

2. A mutant of Parainfluenza type 1 virus with decreased capacity for growth at 38 C and 39 C.

3. Temperature-sensitive mutants of respiratory syncytial virus.

4. Temperature-sensitive mutants of respiratory syncytial virus: in-vivo studies in hamsters.

5. Virulence of temperature-sensitive mutants of influenza virus.

6. Evaluation of influenza virus mutants for possible use in a live virus vaccine.

1. Virulence of temperature-sensitive mutants of foot-and-mouth disease virus.

2. Further observations on the characteristics of a bovine parainfluenza-3 variant.

3. A spontaneous temperature sensitive mutant of Japanese encephalitis virus: preliminary characterization.

4. In vivo behaviour of a temperature-sensitive (ts) mutant of herpesvirus hominis type 2.

5. Isolation and characterization of temperature-sensitive mutants of measles virus.

6. In vivo and in vitro studies on temperature-sensitive mutants of swine vesicular disease virus.

7. Evidence for a mouse pathogenicity locus in certain temperature-sensitive mutants of foot-and-mouth disease virus.