Literature DB >> 5333756

Keto-aldehydes and cell division.

A Szent-Györgyi, L G Együd, J A McLaughlin.   

Abstract

Many problems are left open in this article. Its publication may be excused by the suffering cancer causes, which urges the researcher to publish as soon as he thinks he may have found a new trail, which also may be taken by others. What emerges clearly is that SH groups, with their specific reactivities, offer a hopeful target in the search for cancerostatic substances, among which the natural repressor of cell division may hold out the most promise. The glyoxal derivatives also have antiviral properties (7, 16) and may be in the center of a hitherto unknown system of equilibria which deserves a thorough study. The low molecular weight of the glyoxal derivative reported justifies the hope of an early clarification of its structure, as well as its synthesis (17).

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Year:  1967        PMID: 5333756     DOI: 10.1126/science.155.3762.539

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  23 in total

1.  Glyoxalase II activity in tumours.

Authors:  T Jerzykowski; R Winter; W Matuszewski; Z Szczurek
Journal:  Experientia       Date:  1975-01-15

2.  Alcohol dehydrogenase 1 and NAD(H)-linked methylglyoxal oxidoreductase reciprocally regulate glutathione-dependent enzyme activities in Candida albicans.

Authors:  Sa-Ouk Kang; Min-Kyu Kwak
Journal:  J Microbiol       Date:  2020-12-23       Impact factor: 3.422

3.  Purification of 2-oxoaldehyde dehydrogenase and its dependence on unusual amines.

Authors:  J Dunkerton; S P James
Journal:  Biochem J       Date:  1975-09       Impact factor: 3.857

4.  Oxidation of reduced nicotinamide nucleotides by diamide (NNN'N'-tetramethylazoformamide).

Authors:  J S Brown
Journal:  Biochem J       Date:  1971-09       Impact factor: 3.857

5.  Identification of a bacterial growth inhibitors from HeLa cells: a ketoaldehyde.

Authors:  B G Sparkes; C P Kenny
Journal:  Proc Natl Acad Sci U S A       Date:  1969-11       Impact factor: 11.205

6.  Ketone aldehydes in tissues.

Authors:  L G Együd; J A McLaughlin; A Szent-Györgyi
Journal:  Proc Natl Acad Sci U S A       Date:  1967-05       Impact factor: 11.205

7.  Rapid detection of glyoxalase I (GLO) on cellulose acetate gel and the distribution of GLO variants in a Dutch population.

Authors:  P Meera Khan; B A Doppert
Journal:  Hum Genet       Date:  1976-09-10       Impact factor: 4.132

8.  Lethal synthesis of methylglyoxal by Escherichia coli during unregulated glycerol metabolism.

Authors:  W B Freedberg; W S Kistler; E C Lin
Journal:  J Bacteriol       Date:  1971-10       Impact factor: 3.490

9.  gamma,delta-Dioxovalerate as a substrate for the glyoxalase enzyme system.

Authors:  T Jerzykowski; R Winter; W Matuszewski
Journal:  Biochem J       Date:  1973-12       Impact factor: 3.857

10.  Enzymatic metabolism of 3-deoxyglucosone, a Maillard intermediate.

Authors:  F Hayase; Z Q Liang; Y Suzuki; N van Chuyen; T Shinoda; H Kato
Journal:  Amino Acids       Date:  1991-10       Impact factor: 3.520

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