Literature DB >> 5002644

Neuraminidase and resistance to vaccination with live influenza A2 Hong Kong vaccines.

A N Slepushkin, G C Schild, A S Beare, S Chinn, D A Tyrrell.   

Abstract

Thirty-seven volunteers were inoculated intranasally with living attenuated influenza A2 viruses. Rising titres of circulating antineuraminidase (AN) were detected in 14 of 17 infected volunteers. AN was also found in nasal secretions. Statistical analysis showed that there was a correlation between the titres of haemagglutination-inhibiting antibody (HI) and AN in nasal washings, and between AN in blood and washings. Resistance to infection could be predicted from antibody titres in 29 of 37 volunteers and blood AN alone predicted the outcome of 25 volunteers.

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Year:  1971        PMID： 5002644      PMCID： PMC2131045          DOI： 10.1017/s0022172400021847

Source DB:  PubMed          Journal:  J Hyg (Lond)        ISSN： 0022-1724


  12 in total

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Authors:  L P Tremonti; J S Lin; G G Jackson
Journal:  J Immunol       Date:  1968-09       Impact factor: 5.422

2.  Protective effect of antibody to parainfluenza type 1 virus.

Authors:  C B Smith; R H Purcell; J A Bellanti; R M Chanock
Journal:  N Engl J Med       Date:  1966-11-24       Impact factor: 91.245

3.  Characterization of the ribonucleoprotein and neuraminidase of influenza A viruses by immunodiffusion.

Authors:  G C Schild; H G Pereira
Journal:  J Gen Virol       Date:  1969-04       Impact factor: 3.891

4.  Antibody response in respiratory secretions of volunteers given live and dead influenza virus.

Authors:  J J Mann; R H Waldman; Y Togo; G G Heiner; A T Dawkins; J A Kasel
Journal:  J Immunol       Date:  1968-04       Impact factor: 5.422

5.  Antibody against influenza A2 virus neuraminidase in human sera.

Authors:  G C Schild
Journal:  J Hyg (Lond)       Date:  1969-06

6.  Antigenic composition of recombinant virus strains produced from human and avian influenza A viruses.

Authors:  B Easterday; W G Laver; H G Pereira; G C Schild
Journal:  J Gen Virol       Date:  1969-07       Impact factor: 3.891

7.  Preparation and properties of antibody directed specifically against the neuraminidase of influenza virus.

Authors:  R G Webster; W G Laver
Journal:  J Immunol       Date:  1967-07       Impact factor: 5.422

8.  Antibody response in man to influenza virus neuraminidase following influenza.

Authors:  E D Kilbourne; W N Christenson; M Sande
Journal:  J Virol       Date:  1968-07       Impact factor: 5.103

9.  Antiviral activity of antiserum specific for an influenza virus neuraminidase.

Authors:  E D Kilbourne; W G Laver; J L Schulman; R G Webster
Journal:  J Virol       Date:  1968-04       Impact factor: 5.103

10.  The production of neutralizing activity in serum and nasal secretion following immunization with influenza B virus.

Authors:  J C Downie; C H Stuart-Harris
Journal:  J Hyg (Lond)       Date:  1970-06
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  18 in total

1.  A surface antigen influenza vaccine. 2. Pyrogenicity and antigenicity.

Authors:  M I Brady; I G Furminger
Journal:  J Hyg (Lond)       Date:  1976-10

2.  The response to inactivated influenza A (H3N2) vaccines: the development and effect of antibodies to the surface antigens.

Authors:  A F Smith; J R Davies
Journal:  J Hyg (Lond)       Date:  1977-06

3.  The role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza A2 and B viruses.

Authors:  D Hobson; R L Curry; A S Beare; A Ward-Gardner
Journal:  J Hyg (Lond)       Date:  1972-12

4.  Nasal and circulating antibody responses to influenza vaccination and their importance in resistance to infection.

Authors:  D A Tyrrell; R A Buckland; G C Schild; D S Freestone; S Chinn; A N Slepushkin
Journal:  Postgrad Med J       Date:  1973-03       Impact factor: 2.401

5.  Better influenza vaccines?

Authors: 
Journal:  Br Med J       Date:  1972-09-16

6.  Description of a technique for the analysis of antineuraminidase antibodies oriented to H2N2 and H3N2 influenza virus strains.

Authors:  J Drescher
Journal:  Arch Virol       Date:  1978       Impact factor: 2.574

7.  Antigenic variation in current human type A influenza viruses: antigenic characteristics of the variants and their geographic distribution.

Authors:  G C Schild; M Henry-Aymard; M S Pereira; P Chakraverty; W Dowdle; M Coleman; W K Chang
Journal:  Bull World Health Organ       Date:  1973       Impact factor: 9.408

8.  Antibody responses and resistance to challenge in volunteers vaccinated with live attenuated, detergent split and oil adjuvant A2-Hong Kong-68 (H 3 N 2 ) influenza vaccines. A report to the Medical Research Council Committee on Influenza and other Respiratory Virus Vaccines.

Authors:  D S Freestone; S Hamilton-Smith; G C Schild; R Buckland; S Chinn; D A Tyrrell
Journal:  J Hyg (Lond)       Date:  1972-09

9.  Measurement of antibodies to influenza virus neuraminidase by an enzyme-linked immunosorbent assay.

Authors:  K A Callow
Journal:  Infect Immun       Date:  1983-08       Impact factor: 3.441

10.  Biophysical and immunological studies on the differential effect of guanidine hydrochloride on type A and type B influenza viruses.

Authors:  T S David-West
Journal:  J Hyg (Lond)       Date:  1974-02
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