Literature DB >> 5288380

A bovine pancreatic enzyme catalyzing the conversion of proinsulin to insulin.

C C Yip.   

Abstract

An enzyme that catalyzes the conversion of bovine proinsulin to insulin has been purified from a bovine pancreatic extract. The product of conversion was identified as insulin by aminoacid analysis and determination of carboxyl terminal aminoacid residues. The purified enzyme preparation showed one major protein band on polyacrylamide gel disc electrophoresis; it had a molecular weight of about 70,000 and an isoelectric point (pI) at a pH of 4.82.

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Year:  1971        PMID： 5288380      PMCID： PMC389179          DOI： 10.1073/pnas.68.6.1312

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  14 in total

1.  Carboxy-peptidase B. 4. Purification and characterization of the porcine enzyme.

Authors:  J E FOLK; K A PIEZ; W R CARROLL; J A GLADNER
Journal:  J Biol Chem       Date:  1960-08       Impact factor: 5.157

2.  The biosynthesis of insulin and a probable precursor of insulin by a human islet cell adenoma.

Authors:  D F Steiner; P E Oyer
Journal:  Proc Natl Acad Sci U S A       Date:  1967-02       Impact factor: 11.205

3.  Biosynthesis of insulin in anglerfish islets.

Authors:  A C Trakatellis; G P Schwartz
Journal:  Nature       Date:  1970-02-07       Impact factor: 49.962

4.  Kinetics of the tryptic hydrolysis of zinc-free bovine insulin.

Authors:  S S Wang; F H Carpenter
Journal:  J Biol Chem       Date:  1969-10-25       Impact factor: 5.157

5.  Interaction of zinc with proinsulin.

Authors:  B H Frank; A J Veros
Journal:  Biochem Biophys Res Commun       Date:  1970-01-23       Impact factor: 3.575

6.  The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.

Authors:  K Weber; M Osborn
Journal:  J Biol Chem       Date:  1969-08-25       Impact factor: 5.157

7.  Isolation and properties of proinsulin, intermediate forms, and other minor components from crystalline bovine insulin.

Authors:  D F Steiner; O Hallund; A Rubenstein; S Cho; C Bayliss
Journal:  Diabetes       Date:  1968-12       Impact factor: 9.461

8.  Porcine proinsulin: characterization and amino acid sequence.

Authors:  R E Chance; R M Ellis; W W Bromer
Journal:  Science       Date:  1968-07-12       Impact factor: 47.728

9.  Insulin biosynthesis: evidence for a precursor.

Authors:  D F Steiner; D Cunningham; L Spigelman; B Aten
Journal:  Science       Date:  1967-08-11       Impact factor: 47.728

10.  Biosynthesis of insulin in bovine fetal pancreatic slices: the incorporation of tritiated leucine into a single-chain proinsulin, a double-chain intermediate, and insulin in subcellular fractions.

Authors:  A K Tung; C C Yip
Journal:  Proc Natl Acad Sci U S A       Date:  1969-06       Impact factor: 11.205
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  10 in total

1.  Mechanism of damage to the pancreatic islets in dithisone diabetes.

Authors:  Y A Lazaris; G G Meiramov
Journal:  Bull Exp Biol Med       Date:  1974-09       Impact factor: 0.804

2.  Proparathyroid hormone: identification of a biosynthetic precursor to parathyroid hormone.

Authors:  B Kemper; J F Habener; J T Potts; A Rich
Journal:  Proc Natl Acad Sci U S A       Date:  1972-03       Impact factor: 11.205

Review 3.  Multiple forms of gastroenteropancreatic hormones.

Authors:  G B Irvine; R F Murphy
Journal:  Gut       Date:  1981-12       Impact factor: 23.059

4.  Proteolytic conversion of proinsulin into insulin. Identification of a Ca2+-dependent acidic endopeptidase in isolated insulin-secretory granules.

Authors:  H W Davidson; M Peshavaria; J C Hutton
Journal:  Biochem J       Date:  1987-09-01       Impact factor: 3.857

5.  In vitro conversion of proinsulin to insulin by cathepsin B and role of C-peptide.

Authors:  R B Puri; K Anjaneyulu; J R Kidwai; V K Mohan Rao
Journal:  Acta Diabetol Lat       Date:  1978 Sep-Dec

6.  Differences in the nature of the interaction of insulin and proinsulin with zinc.

Authors:  P T Grant; T L Coombs; B H Frank
Journal:  Biochem J       Date:  1972-01       Impact factor: 3.857

7.  Sequential cleavage of proinsulin by human pancreatic kallikrein and a human pancreatic kininase.

Authors:  O O Yoi; D C Seldin; J Spragg; G S Pinkus; K F Austen
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

8.  Role of zinc in insulin biosynthesis. Some possible zinc-insulin interactions in the pancreatic B-cell.

Authors:  S O Emdin; G G Dodson; J M Cutfield; S M Cutfield
Journal:  Diabetologia       Date:  1980-09       Impact factor: 10.122

Review 9.  Zinc transporters and their role in the pancreatic β-cell.

Authors:  Katleen Lemaire; Fabrice Chimienti; Frans Schuit
Journal:  J Diabetes Investig       Date:  2012-06-06       Impact factor: 4.232

10.  Characterization of proinsulin- and proglucagon-converting activities in isolated islet secretory granules.

Authors:  D J Fletcher; J P Quigley; G E Bauer; B D Noe
Journal:  J Cell Biol       Date:  1981-08       Impact factor: 10.539
  10 in total

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