Literature DB >> 5288236

Amino acid sequence of the light chain from a mouse myeloma protein with anti-hapten activity: evidence for a third type of light chain.

E P Schulenburg, E S Simms, R G Lynch, R A Bradshaw, H N Eisen.   

Abstract

A tentative amino acid sequence has been determined for the light chain of a mouse A-myeloma (MOPC-315) protein with anti-2,4-dinitrophenyl activity. An unusual amino acid sequence in the carboxyl-terminal 104 residues suggests that the chain represents a new class of immunoglobulin light chain. The "variable" segment of this chain (amino-terminal 110 residues) differs at only eight positions from the corresponding segment of the lambda chain of a mouse M-myeloma (MOPC-104) protein with anti-dextran activity.

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Year:  1971        PMID： 5288236      PMCID： PMC389486          DOI： 10.1073/pnas.68.11.2623

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

1.  Mechanism of antibody synthesis: size differences between mouse kappa chains.

Authors:  W R Gray; W J Dreyer; L Hood
Journal:  Science       Date:  1967-01-27       Impact factor: 47.728

2.  Two types of lambda polypeptide chains in human immunoglobulins based on an amino acid substitution at position 190.

Authors:  E Appella; D Ein
Journal:  Proc Natl Acad Sci U S A       Date:  1967-05       Impact factor: 11.205

3.  Mouse myelomas producing precipitating antibody to nucleic acid bases and-or nitrophenyl derivatives.

Authors:  D Schubert; A Jobe; M Cohn
Journal:  Nature       Date:  1968-11-30       Impact factor: 49.962

Review 4.  The antibody problem.

Authors:  G M Edelman; W E Gall
Journal:  Annu Rev Biochem       Date:  1969       Impact factor: 23.643

5.  Experimental approaches to homogenous antibody populations. Factors controlling the occurrence of antibodies with uniform properties.

Authors:  R M Krause
Journal:  Fed Proc       Date:  1970 Jan-Feb

6.  The amino acid sequence of bovine carboxypeptidase A. II. Tryptic and chymotryptic peptides of the cyanogen bromide fragment F-III.

Authors:  R A Bradshaw; D R Babin; M Nomoto; N G Srinivasin; L H Ericsson; K A Walsh; H Neurath
Journal:  Biochemistry       Date:  1969-09       Impact factor: 3.162

7.  Separation of the alpha and beta-chains of human hemoglobin.

Authors:  J B Clegg; M A Naughton; D J Weatherall
Journal:  Nature       Date:  1968-07-06       Impact factor: 49.962

8.  Macroglobulin structure: homology of mu and gamma heavy chains of human immunoglobulins.

Authors:  M Wikler; H Köhler; T Shinoda; F W Putnam
Journal:  Science       Date:  1969-01-03       Impact factor: 47.728

9.  Nonallelic behavior of the Oz groups in human lambda immunoglobulin chains.

Authors:  D Ein
Journal:  Proc Natl Acad Sci U S A       Date:  1968-07       Impact factor: 11.205

10.  Specificity of recombination of H and L chains from human gamma-G-myeloma proteins.

Authors:  H M Grey; M Mannik
Journal:  J Exp Med       Date:  1965-09-01       Impact factor: 14.307
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  13 in total

1.  Dendritic cells purified from myeloma are primed with tumor-specific antigen (idiotype) and activate CD4+ T cells.

Authors:  Z Dembic; K Schenck; B Bogen
Journal:  Proc Natl Acad Sci U S A       Date:  2000-03-14       Impact factor: 11.205

2.  Localization of antibody-combining sites within the variable portions of heavy and light chains.

Authors:  D Inbar; J Hochman; D Givol
Journal:  Proc Natl Acad Sci U S A       Date:  1972-09       Impact factor: 11.205

3.  Lambda2 light chains in normal mouse immunoglobulins.

Authors:  K Blaser; H N Eisen
Journal:  Proc Natl Acad Sci U S A       Date:  1978-03       Impact factor: 11.205

4.  Amino-acid sequence of the variable region of the heavy (alpha) chain of a mouse myeloma protein with anti-hapten activity.

Authors:  S H Francis; R G Leslie; L Hood; H N Eisen
Journal:  Proc Natl Acad Sci U S A       Date:  1974-04       Impact factor: 11.205

5.  Identification of a third type of lambda light chain in mouse immunoglobulins.

Authors:  T Azuma; L A Steiner; H N Eisen
Journal:  Proc Natl Acad Sci U S A       Date:  1981-01       Impact factor: 11.205

6.  Transcription in vitro of immunoglobulin kappa light chain genes in isolated mouse myeloma nuclei and chromatin.

Authors:  M M Smith; R C Huang
Journal:  Proc Natl Acad Sci U S A       Date:  1976-03       Impact factor: 11.205

7.  Myeloma proteins as tumor-specific transplantation antigens.

Authors:  R G Lynch; R J Graff; S Sirisinha; E S Simms; H N Eisen
Journal:  Proc Natl Acad Sci U S A       Date:  1972-06       Impact factor: 11.205

8.  Cell-bound myeloma proteins on the surface of myeloma cells: potential targets for the immune system.

Authors:  K Hannestad; M S Kao; H N Eisen
Journal:  Proc Natl Acad Sci U S A       Date:  1972-08       Impact factor: 11.205

9.  Localization of idiotypic antigenic determinants in the Fv region of murine myeloma protein MOPC-315.

Authors:  J V Wells; H H Fudenberg; D Givol
Journal:  Proc Natl Acad Sci U S A       Date:  1973-05       Impact factor: 11.205

10.  Reaction of anti-idiotypic antibody with the hapten-binding site of a myeloma protein.

Authors:  B W Brient; J Haimovich; A Nisonoff
Journal:  Proc Natl Acad Sci U S A       Date:  1971-12       Impact factor: 11.205
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