Literature DB >> 5271752

Genetics of somatic mammalian cells. X. Complementation analysis of glycine-requiring mutants.

F Kao, L Chasin, T T Puck.   

Abstract

Complementation analysis at the single gene level has been carried out on 13 different, recessive, glycine-requiring mutants produced by action of mutagenic agents on the CHO-K1 Chinese hamster cell. The mutants form four different complementation classes indicating that at least four separate genes can produce a growth requirement for glycine. The four classes of mutants can be distinguished biochemically as well as genetically. Existence of these four mutant classes appears to explain the preponderance of the glycine-requiring forms in the auxotrophs produced by treatment of the parental cell with mutagenic agents.

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Year:  1969        PMID： 5271752      PMCID： PMC223281          DOI： 10.1073/pnas.64.4.1284

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  10 in total

1.  FURTHER STUDIES ON DIHYDROFOLIC REDUCTASE.

Authors:  C K MATHEWS; F M HUENNEKENS
Journal:  J Biol Chem       Date:  1963-10       Impact factor: 5.157

2.  CLONAL GROWTH OF MAMMALIAN CELLS IN A CHEMICALLY DEFINED, SYNTHETIC MEDIUM.

Authors:  R G HAM
Journal:  Proc Natl Acad Sci U S A       Date:  1965-02       Impact factor: 11.205

3.  Relation of folic acid reductase to amethopterin resistance in cultured mammalian cells.

Authors:  M T HAKALA; S F ZAKRZEWSKI; C A NICHOL
Journal:  J Biol Chem       Date:  1961-03       Impact factor: 5.157

4.  The determination of formaldehyde and serine in biological systems.

Authors:  W R FRISELL; C G MACKENZIE
Journal:  Methods Biochem Anal       Date:  1958

5.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

6.  Induction of dihydrofolate reductase activity by SV40 and polyoma virus.

Authors:  P M Frearson; S Kit; D R Dubbs
Journal:  Cancer Res       Date:  1966-08       Impact factor: 12.701

7.  Studies on serine hydroxymethylase isoenzymes from rat liver.

Authors:  Y Nakano; M Fujioka; H Wada
Journal:  Biochim Biophys Acta       Date:  1968-04-24

8.  Complementation analysis on virus-fused Chinese hamster cells with nutritional markers.

Authors:  F T Kao; R T Johnson; T T Puck
Journal:  Science       Date:  1969-04-18       Impact factor: 47.728

9.  Genetics of somatic mammalian cells, VII. Induction and isolation of nutritional mutants in Chinese hamster cells.

Authors:  F T Kao; T T Puck
Journal:  Proc Natl Acad Sci U S A       Date:  1968-08       Impact factor: 11.205

10.  Genetics of somatic mammalian cells. IV. Properties of Chinese hamster cell mutants with respect to the requirement for proline.

Authors:  F T Kao; T T Puck
Journal:  Genetics       Date:  1967-03       Impact factor: 4.562
  10 in total
  45 in total

1.  Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation.

Authors:  Mohit Jain; Roland Nilsson; Sonia Sharma; Nikhil Madhusudhan; Toshimori Kitami; Amanda L Souza; Ran Kafri; Marc W Kirschner; Clary B Clish; Vamsi K Mootha
Journal:  Science       Date:  2012-05-25       Impact factor: 47.728

2.  Rickettsia prowazekii requires host cell serine and glycine for growth.

Authors:  F E Austin; J Turco; H H Winkler
Journal:  Infect Immun       Date:  1987-01       Impact factor: 3.441

3.  Genetic construction, expression, and melanoma-selective cytotoxicity of a diphtheria toxin-related alpha-melanocyte-stimulating hormone fusion protein.

Authors:  J R Murphy; W Bishai; M Borowski; A Miyanohara; J Boyd; S Nagle
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

4.  V(D)J recombination intermediates and non-standard products in XRCC4-deficient cells.

Authors:  J O Han; L A Erskine; M M Purugganan; T D Stamato; D B Roth
Journal:  Nucleic Acids Res       Date:  1998-08-15       Impact factor: 16.971

5.  Genetic complementation among inherited deficiencies of methylmalonyl-CoA mutase activity: evidence for a new class of human cobalamin mutant.

Authors:  H F Willard; I S Mellman; L E Rosenberg
Journal:  Am J Hum Genet       Date:  1978-01       Impact factor: 11.025

6.  Cell-to-cell contact as an efficient mode of Epstein-Barr virus infection of diverse human epithelial cells.

Authors:  S Imai; J Nishikawa; K Takada
Journal:  J Virol       Date:  1998-05       Impact factor: 5.103

Review 7.  Somatic cell fusion as a source of genetic rearrangement leading to metastatic variants.

Authors:  L Larizza; V Schirrmacher
Journal:  Cancer Metastasis Rev       Date:  1984       Impact factor: 9.264

8.  Genetics of somatic mammalian cells: demonstration of a human esterase activator gene linked to the adeB gene.

Authors:  F T Kao; T T Puck
Journal:  Proc Natl Acad Sci U S A       Date:  1972-11       Impact factor: 11.205

9.  Human mitochondrial C1-tetrahydrofolate synthase: submitochondrial localization of the full-length enzyme and characterization of a short isoform.

Authors:  Priya Prasannan; Dean R Appling
Journal:  Arch Biochem Biophys       Date:  2008-10-29       Impact factor: 4.013

10.  Genetics of somatic mammalian cells: biochemical genetics of Chinese hamster cell mutants with deviant purine metabolism.

Authors:  D Patterson; F T Kao; T T Puck
Journal:  Proc Natl Acad Sci U S A       Date:  1974-05       Impact factor: 11.205
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