Literature DB >> 5269255

Tolerance to opioid narcotics, II. Cellular tolerance to levorphanol in mouse brain.

J A Richter, A Goldstein.   

Abstract

Mice were made tolerant to a large dose of levorphanol, a congener of morphine. Then (3)H-levorphanol was given. The concentration of free, unchanged levorphanol in the brain water (ultrafiltrate) was found to be much higher than required to produce pharmacologic effects in nontolerant animals. The result indicates that tolerance arises from a diminished sensitivity to the drug at cellular or subcellular sites of drug action in the brain.

Entities:  

Mesh：

Substances：

Year:  1970        PMID： 5269255      PMCID： PMC283142          DOI： 10.1073/pnas.66.3.944

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  7 in total

1.  Concentration of morphine in blood and brain after intravenous injection of morphine in non-tolerant, tolerant and neostigmine-treated rats.

Authors:  D H MCCURDY; J C SZERB
Journal:  J Pharmacol Exp Ther       Date:  1956-12       Impact factor: 4.030

2.  The distribution and fate of morphine in the non-tolerant and tolerant monkey.

Authors:  L B MELLETT; L A WOODS
Journal:  J Pharmacol Exp Ther       Date:  1956-01       Impact factor: 4.030

3.  Plasma levels, urinary and fecal excretion of morphine in non-tolerant and tolerant dogs.

Authors:  J COCHIN; J HAGGART; L A WOODS; M H SEEVERS
Journal:  J Pharmacol Exp Ther       Date:  1954-05       Impact factor: 4.030

4.  Distribution of N-C-14-methyl labeled morphine. I. In central nervous system of nontolerant and tolerant dogs.

Authors:  S J MULE; L A WOODS
Journal:  J Pharmacol Exp Ther       Date:  1962-05       Impact factor: 4.030

5.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

6.  Tolerance to opioid narcotics. I. Tolerance to the "running fit" caused by levorphanol in the mouse.

Authors:  A Goldstein; P Sheehan
Journal:  J Pharmacol Exp Ther       Date:  1969-10       Impact factor: 4.030

7.  Induction of morphine tolerance by material extracted from brain of tolerant animals.

Authors:  G Ungar; M Cohen
Journal:  Int J Neuropharmacol       Date:  1966-03
  7 in total
  6 in total

Review 1.  [Recent views on the biochemical aspects of the mode of action of analgesics acting like morphine in the central nervous system].

Authors:  K Kuschinsky
Journal:  Klin Wochenschr       Date:  1972-04-15

2.  Quantitative assessment of tolerance to and dependence on morphine in mice.

Authors:  M Fernandes; S Kluwe; H Coper
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-03       Impact factor: 3.000

3.  An electron spin resonance study of synaptosome opiate receptors. The preparation and use of a spin labeled morphine.

Authors:  E S Copeland; M E Boykin; J A Kelley; M P Kullberg
Journal:  Biophys J       Date:  1975-11       Impact factor: 4.033

4.  Cellular and metabolic tolerance to an opioid narcotic in mouse brain.

Authors:  A Goldstein; B A Judson; P Sheehan
Journal:  Br J Pharmacol       Date:  1973-01       Impact factor: 8.739

5.  Stereospecific and nonspecific interactions of the morphine congener levorphanol in subcellular fractions of mouse brain.

Authors:  A Goldstein; L I Lowney; B K Pal
Journal:  Proc Natl Acad Sci U S A       Date:  1971-08       Impact factor: 11.205

6.  Pharmacological Characterization of Levorphanol, a G-Protein Biased Opioid Analgesic.

Authors:  Valerie Le Rouzic; Ankita Narayan; Amanda Hunkle; Gina F Marrone; Zhigang Lu; Susruta Majumdar; Jin Xu; Ying-Xian Pan; Gavril W Pasternak
Journal:  Anesth Analg       Date:  2019-02       Impact factor: 5.108
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.