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Literature DB >> 1201330

An electron spin resonance study of synaptosome opiate receptors. The preparation and use of a spin labeled morphine.

E S Copeland, M E Boykin, J A Kelley, M P Kullberg.

Abstract

Morphine spin labeled on the phenolic hydroxy group has been prepared using commercially available reagents and characterized by thin layer chromatography, mass spectroscopy, and electron spin resonance spectroscopy. It has been shown that morphine modified in this way retains some opiate activity, does not pass through the blood-brain barrier, and specifically binds to isolate rat brain synaptosomes. Spin labeled morphine has been shown to be an effective biophysical probe complementing radioactive tracer techniques in the study of the narcotic receptor site.

Entities: Chemical Species

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Year: 1975 PMID： 1201330 PMCID： PMC1334794 DOI： 10.1016/S0006-3495(75)85889-9

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

19 in total

1. Mass spectral studies of alkaloids related to morphine.

Authors: D M Wheeler; T H Kinstle; K L Rinehart
Journal: J Am Chem Soc Date: 1967-08-16 Impact factor: 15.419

2. The effect of ambient temperature on spin-label immunoassay for morphine.

Authors: E S Copeland
Journal: Ann N Y Acad Sci Date: 1973-12-31 Impact factor: 5.691

3. Interaction of a spin-labeled analog of nicotinamide-adenine dinucleotide with alcohol dehydrogenase. I. Synthesis, kinetics, and electron paramagnetic resonance studies.

Authors: H Weiner
Journal: Biochemistry Date: 1969-02 Impact factor: 3.162

4. Stereospecific interaction between narcotic analgesics and a synaptic plasm a membrane fraction of rat cerebral cortex.

Authors: L Terenius
Journal: Acta Pharmacol Toxicol (Copenh) Date: 1973

9. Electron spinal resonance analysis of the nitroxide spin label 2,2,6,6-tetramethylpipidone-N-oxyl (Tempone) in single crystals of the reduced Tempone matrix.

Authors: W Snipes; J Cupp; G Cohn; A Keith
Journal: Biophys J Date: 1974-01 Impact factor: 4.033

10. Tolerance to opioid narcotics, II. Cellular tolerance to levorphanol in mouse brain.

Authors: J A Richter; A Goldstein
Journal: Proc Natl Acad Sci U S A Date: 1970-07 Impact factor: 11.205

1 in total

1. Electron spin resonance study of the synaptosome opiate receptor: kinetics of stereospecific binding of spin labeled morphine.

Authors: E S Copeland; L deBaare
Journal: Biophys J Date: 1976-11 Impact factor: 4.033

1 in total

An electron spin resonance study of synaptosome opiate receptors. The preparation and use of a spin labeled morphine.

1. Mass spectral studies of alkaloids related to morphine.

2. The effect of ambient temperature on spin-label immunoassay for morphine.

3. Interaction of a spin-labeled analog of nicotinamide-adenine dinucleotide with alcohol dehydrogenase. I. Synthesis, kinetics, and electron paramagnetic resonance studies.

4. Stereospecific interaction between narcotic analgesics and a synaptic plasm a membrane fraction of rat cerebral cortex.

5. Opiate receptor: demonstration in nervous tissue.

6. Preliminary observations on the uptake of catecholamines in synaptosomes of opiate-treated animals.

7. Cellular and metabolic tolerance to an opioid narcotic in mouse brain.

8. A neuroblastoma times glioma hybrid cell line with morphine receptors.

9. Electron spinal resonance analysis of the nitroxide spin label 2,2,6,6-tetramethylpipidone-N-oxyl (Tempone) in single crystals of the reduced Tempone matrix.

10. Tolerance to opioid narcotics, II. Cellular tolerance to levorphanol in mouse brain.

1. Electron spin resonance study of the synaptosome opiate receptor: kinetics of stereospecific binding of spin labeled morphine.